Bioaccessibility of arsenic from gastropod along the Xiangjiang River: Assessing human health risks using an in vitro digestion model
Bioaccessibility of arsenic from gastropod along the Xiangjiang River: Assessing human health risks using an in vitro digestion model
复制标题
湘江沿岸腹足动物砷的生物可及性：利用体外消化模型评估人类健康风险
DOI：
10.1016/j.ecoenv.2020.110334
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发表时间：
2020
影响因子：
6.8
通讯作者：
Ting Zhang
中科院分区：
文献类型：
--
作者：
Rongtao Lyu;Zhixiang Gao;Deliang Li;Zhaoguang Yang;Ting Zhang
采用体外消化模型对湘江铜绿贝拉米亚中总砷（tAs）和砷形态的生物可及性进行评估，以评估对当地居民的潜在健康风险。腹足动物样品中的 tAs 浓度范围为 1.98 至 6.33 mg kg−1（平均 3.79 ± 1.60 mg kg−1）。检测到五种砷，包括亚砷酸盐[As(III)]、砷酸盐[As(V)]、二甲基胂酸(DMA)、砷甜菜碱(AsB)和砷胆碱(AsC)。无机砷（iAs）浓度约为有机砷（oAs）的一半，高于最高允许限量（水产品中≤0.50 mg kg−1）。研究发现，消化液中 tAs 的生物可利用浓度按以下顺序降低：肠相 > 胃相 > 唾液相。 As(III) 和 AsC 是主要种类，但并非所有消化液中都检测到 AsB。生物可获取的 iAs 浓度接近生物可获取的 oAs 水平，在三种消化液中没有显着差异，但也高于 0.50 mg kg−1。因此，tAs 的生物可及性在肠相最高（48%），然后在胃相（40%），在唾液相最低（33%）。 As(III)的生物可及性接近100%，iAs的生物可及性远高于oAs。目标危险商 (THQ) 和生物可利用 THQ 的平均值分别为 0.80 和 0.70。考虑到 iAs 的生物可利用性，出现非致癌作用的概率从 22% 降至 18%。致癌风险 (CR) 和生物可及性 CR 的平均值高于可接受值 (1 × 10−4)。采样地点的腹足动物食用可能会导致潜在的致癌风险。
The bioaccessibility of total arsenic (tAs) and arsenic species inBellamya aeruginosacollected from Xiangjiang River was evaluated using anin vitrodigestion model, to assess the potential health risks to local residents. The tAs concentrations in gastropod samples ranged from 1.98 to 6.33 mg kg−1(mean 3.79 ± 1.60 mg kg−1). Five arsenic species including arsenite [As(III)], arsenate [As(V)], dimethylarsinic acid (DMA), arsenobetaine (AsB), and arsenocholine (AsC) were detected. Inorganic arsenic (iAs) concentrations, which were about a half of organic arsenic (oAs), were higher than the maximum permissible limit (≤0.50 mg kg−1in aquatic products). Bioaccessible concentrations of tAs in digestive juices were found to be decreased in the order: intestinal phase > gastric phase > salivary phase. As(III) and AsC were the predominant species, but AsB was not detectable in all digestive juices. Bioaccessible iAs concentrations, which were close to the level of bioaccessible oAs, were not significantly different among three digestive juices, but also above 0.50 mg kg−1. Accordingly, bioaccessibility of tAs was highest in intestinal phase (48%), then in gastric phase (40%), and lowest in salivary phase (33%). Bioaccessibility of As(III) was close to 100%, and bioaccessibility of iAs was much higher than that of oAs. The mean values of target hazard quotient (THQ) and bioaccessible THQ were 0.80 and 0.70, respectively. The probability of experiencing non-carcinogenic effects was reduced to 18% down from 22% as considering iAs bioaccessibility. The mean values of carcinogenic risk (CR) and bioaccessible CR were higher than the acceptable value (1 × 10−4). Gastropod consumption from sampling sites may cause a potential carcinogenic risk.