Biomonitoring of chemical exposure among New York City firefighters responding to the World Trade Center fire and collapse.
Biomonitoring of chemical exposure among New York City firefighters responding to the World Trade Center fire and collapse.
复制标题
纽约市消防员对世界贸易中心火灾和崩溃的反应化学暴露的生物监测。
DOI：
10.1289/ehp.6315
复制
发表时间：
2003-12
影响因子：
10.4
通讯作者：
Prezant, David
中科院分区：
文献类型：
--
作者：
Edelman, Philip;Osterloh, John;Pirkle, James;Caudill, Sam P;Grainger, James;Jones, Robert;Blount, Ben;Calafat, Antonia;Turner, Wayman;Feldman, Debra;Baron, Sherry;Bernard, Bruce;Lushniak, Boris D;Kelly, Kerry;Prezant, David
2001年9月11日世界贸易中心（WTC）的倒塌使纽约市的消防员暴露在前所未有的规模和持续时间的烟雾和灰尘中。任何火灾产生的化学物质和浓度都难以预测，但内部剂量暴露的估计可以通过血液和尿液的生物监测来评估。我们分析了321名参与世贸中心火灾和倒塌的消防员的血液和尿液样本，其中有110种可能与火灾有关的化学物质。控制人员包括47名不在世贸中心的消防员。采样是在9月11日之后3周进行的，当时火灾仍在燃烧。当有参考或背景范围时，发现大多数化学物质的浓度普遍较低，而不是超出这些范围。与对照组相比，暴露的消防员在六种化学物质的调整几何平均值上表现出显著差异，在另外三种化学物质的检测率上表现出显著提高。到达时间是四种化学物质的显著预测变量。特种作战司令部消防员（n = 95）与其他世贸中心消防员（n = 226）相比，在14种化学物质的浓度或检出率上存在差异。对于同样的化学物质和另外两种化学物质，特种作战司令部消防员的数值也与对照组显著不同。一般来说，其他消防员组的化学物质浓度与对照组没有差异。生物监测被用于描述世贸中心灾难中消防员的暴露情况。虽然分析的一些化学物质显示出统计学上的显著差异，但这些差异通常很小。
The collapse of the World Trade Center (WTC) on 11 September 2001 exposed New York City firefighters to smoke and dust of unprecedented magnitude and duration. The chemicals and the concentrations produced from any fire are difficult to predict, but estimates of internal dose exposures can be assessed by the biological monitoring of blood and urine. We analyzed blood and urine specimens obtained from 321 firefighters responding to the WTC fires and collapse for 110 potentially fire-related chemicals. Controls consisted of 47 firefighters not present at the WTC. Sampling occurred 3 weeks after 11 September, while fires were still burning. When reference or background ranges were available, most chemical concentrations were found to be generally low and not outside these ranges. Compared with controls, the exposed firefighters showed significant differences in adjusted geometric means for six of the chemicals and significantly greater detection rates for an additional three. Arrival time was a significant predictor variable for four chemicals. Special Operations Command firefighters (n = 95), compared with other responding WTC firefighters (n = 226), had differences in concentrations or detection rate for 14 of the chemicals. Values for the Special Operations Command firefighters were also significantly different from the control group values for these same chemicals and for two additional chemicals. Generally, the chemical concentrations in the other firefighter group were not different from those of controls. Biomonitoring was used to characterize firefighter exposure at the WTC disaster. Although some of the chemicals analyzed showed statistically significant differences, these differences were generally small.