Multislice continuous arterial spin-labeled perfusion MRI in patients with chronic occlusive cerebrovascular disease:: A correlative study with CO2PET validation
Multislice continuous arterial spin-labeled perfusion MRI in patients with chronic occlusive cerebrovascular disease:: A correlative study with CO2PET validation
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DOI：
10.1002/jmri.20382
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发表时间：
2005-08-01
影响因子：
4.4
通讯作者：
Itoh, H
中科院分区：
文献类型：
--
作者：
Kimura, H;Kado, H;Itoh, H
目的：比较使用多层连续动脉自旋标记（CASL）和CO（2）正电子发射断层扫描（PET）评估慢性闭塞性脑血管病患者的CBF，以验证定量CASL灌注在改变血流动力学state.Materials和方法：11例闭塞性颈动脉疾病患者进行了研究与CASL和常规MRI。脑血流量（CBF）也用O（15）标记的CO（2）气体使用全身PET扫描仪测量。结果：所有患者的CASL和PET的CBF值之间存在显著的相关性（r = 0.71 ± 0.07，P < 0.001）。回归线的斜率在患者之间变化很大（0.54-1.77）。较长的过境时间估计在四个I I患者在低灌注region.Conclusion：定量CBF使用CASL是可行的，合理的，即使在常规的临床设置。然而，在闭塞性脑血管病中，较长的通过时间可能导致对患侧的低估。
Purpose: To compare the use of multislice continuous arterial spin labeling (CASL) and CO(2) positron emission tomography (PET) to assess CBF in patients with chronic occlusive cerebrovascular disease for the validation of quantitative CASL per-fusion in an altered hemodynamic state.Materials and Methods: Eleven patients with occlusive carotid artery disease were studied with CASL and conventional MRI. Cerebral blood flow (CBF) was also measured with O(15)-labeled CO(2) gas using a whole-body PET scanner. The average values within region of interests (ROIs) drawn on coregistered CASL and PET images were used for the linear regression analysis and to assess the effect of transit time on the quantification using CASL.Result: In all patients there was a significant correlation between the CBF values from CASL and PET (r = 0.71 +/- 0.07, P < 0.001). The slope of regression lines varied widely among patients (0.54-1.77). Longer transit times were estimated in four of I I patients in the hypoperfusion region.Conclusion: Quantification of CBF using CASL is feasible and reasonable, even when employed in a routine clinical setting. However, the long transit time may lead to underestimation of the affected side in occlusive cerebrovascular disease.