Depigmented atrophic lesions in sunset glow fundi of Vogt-Koyanagi-Harada disease
Depigmented atrophic lesions in sunset glow fundi of Vogt-Koyanagi-Harada disease
复制标题
DOI：
10.1016/s0002-9394(00)00851-5
复制
发表时间：
2001-05-01
影响因子：
4.2
通讯作者：
Rao, NA
中科院分区：
文献类型：
--
作者：
Inomata, H;Rao, NA
目得：尽管Vogt-Koyanagi-Harada病的晚霞眼底可见的色素脱失、小的圆形至椭圆形病变被认为是Dalen-Fuchs结节，但没有组织病理学证据支持这种考虑。本文试图澄清的萎缩性病变的性质，并区分它们与Dalen-Fuchs结节中看到的眼睛与Vogt-小柳原田diseases.METHODS：眼睛从bye个人与临床诊断的沃格特小柳原田病进行了组织病理学检查。评价了从早期活动期到恢复期和晚期慢性复发期的视网膜色素上皮变化，特别注意达伦富克斯结节、晚霞眼底色素脱失病变和慢性复发期色素沉着过度。两个人的眼睛，一个在Vogt-Koyanagi-Harada病的活动期，另一个在恢复期，显示存在Dalen-Fuchs结节，2例患者均表现为恢复期的晚霞眼底，表现为视网膜色素上皮细胞的损伤或消失，晚霞眼底表现为脉络膜黑色素细胞的丢失。结论：Dalen-Fuchs结节是沃格特Koyanagi-Harada病患者视网膜色素上皮水平上的一种特异性组织学改变。没有组织学证实Vogt-小柳-原田病的晚霞眼底所见的色素脱失的小萎缩性病变是Dalen-Fuchs结节。色素脱失病变代表视网膜色素上皮细胞的局部损伤或消失。(C)2001年，Elsevier Science Inc.版权所有© 2016
PURPOSE: Although the depigmented, small, round to oval lesions seen in the sunset glow fundi of Vogt-Koyanagi-Harada disease are considered to represent Dalen-Fuchs nodules, there is no histopathologic evidence to support such a consideration. An attempt is made herein to clarify the nature of the atrophic lesions and distinguish them from Dalen-Fuchs nodules seen in eyes with Vogt-Koyanagi-Harada disease.METHODS: Eyes from bye individuals with clinical diagnoses of Vogt Koyanagi-Harada disease were subjected to histopathologic examination. The retinal pigment epithelial changes from early active to convalescent and late chronic recurrent stages were evaluated, Particular attention was paid to Dalen Fuchs nodules, depigmented lesions in the sunset glow fundi, and hyperpigmentation of the chronic recurrent stage.RESULTS: Eyes of two individuals, one in the active stage of Vogt-Koyanagi-Harada disease and the other in the convalescent stage, showed the presence of Dalen-Fuchs nodules, The depigmented small retinal pigment epithelial lesions were seen in two individuals, both of whom exhibited the sunset glow fundus of the convalescent stage, The retinal pigment epithelial lesions repre- sented damage or disappearance of retinal pigment epithelial cells, and the sunset glow fundus appearance was from the loss of choroidal melanocytes. The heavy pigmentation seen in fundi with the chronic recurrent stage was the result of the proliferation of retinal pigment epithelial cells.CONCLUSION: The Dalen-Fuchs nodule is a specific histologic change observed at the level of retinal pigment epithelium in patients with Vogt Koyanagi-Harada disease. There is no histologic confirmation that the depigmented small atrophic lesions seen in the sunset glow fundi of Vogt-Koyanagi-Harada disease are Dalen-Fuchs nodules. The depigmented lesions represent localized damage or disappearance of retinal pigment epithelial cells. (C) 2001 by Elsevier Science Inc. All rights reserved.).