Protocol for the Arterial Revascularisation Trial (ART). A randomised trial to compare survival following bilateral versus single internal mammary grafting in coronary revascularisation [ISRCTN46552265].
Protocol for the Arterial Revascularisation Trial (ART). A randomised trial to compare survival following bilateral versus single internal mammary grafting in coronary revascularisation [ISRCTN46552265].
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动脉血运重建试验（ART）方案。一项随机试验，比较双侧与单个内部乳腺移植后的存活率[ISRCTN46552265]。
DOI：
10.1186/1745-6215-7-7
复制
发表时间：
2006-03-30
期刊：
影响因子：
2.5
通讯作者：
Channon, K
中科院分区：
文献类型：
--
作者：
Taggart, DP;Lees, B;Gray, A;Altman, DG;Flather, M;Channon, K
标准的冠状动脉搭桥手术使用单个乳腺内动脉和补充静脉或桡动脉移植物。几项观察性研究表明，两次乳腺内动脉移植比一次乳腺内动脉移植更有利于生存，但这尚未在随机试验中得到验证。动脉血管重建试验是医学研究委员会和英国心脏基金会资助的一项多中心国际试验，比较单乳房内动脉移植与双侧乳房内动脉移植。英国、澳大利亚、波兰和巴西的20个中心正计划随机抽取3000名冠状动脉搭桥手术患者进行单侧或双侧乳腺内动脉移植。补充移植物可以是隐静脉或桡动脉。冠状动脉旁路移植术可以进行有泵或无泵手术。主要终点是10年生存率，次要终点包括临床事件、生活质量和成本效益。年龄、左心室功能、糖尿病、移植物数量、静脉移植物和非泵手术的影响是预先指定的亚组。动脉血运重建试验是首批评估单乳内动脉移植术与双乳内动脉移植术对生存率和其他临床结果影响的随机试验之一，将有助于为需要冠状动脉搭桥手术的患者建立最佳方法。
Standard coronary artery bypass graft surgery uses a single internal mammary artery and supplemental vein or radial artery grafts. Several observational studies have suggested a survival benefit with two internal mammary artery grafts compared to a single internal mammary artery graft, but this has not been tested in a randomised trial. The Arterial Revascularisation Trial is a Medical Research Council and British Heart Foundation funded, multi-centre international trial comparing single internal mammary artery grafting versus bilateral internal mammary artery grafting. Twenty centres in the UK, Australia, Poland and Brazil are planning to randomise 3000 coronary artery bypass graft surgery patients to single or bilateral internal mammary artery grafting. Supplemental grafts may be either saphenous vein or radial artery. Coronary artery bypass grafting can be performed as an on-pump or off-pump procedure. The primary outcome is survival at 10 years and secondary end-points include clinical events, quality of life and cost effectiveness. The effect of age, left ventricular function, diabetes, number of grafts, vein grafts and off-pump surgery are pre-specified subgroups. The Arterial Revascularisation Trial is one of the first randomised trials to evaluate the effects on survival and other clinical outcomes of single internal mammary artery grafting versus bilateral internal mammary artery grafting, and will help to establish the best approach for patients requiring coronary artery bypass graft surgery.
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DOI：
10.1016/0967-2109(96)82318-0
发表时间：
1996-04-01
期刊：
Cardiovascular surgery (London, England)
影响因子：
--
作者：
Verhelst, R;Etienne, P Y;Dion, R
通讯作者：
Dion, R
DOI：
10.1016/s0022-5223(99)70188-1
发表时间：
1999-09-01
影响因子：
6
作者：
Cohen, AJ;Lockman, J;Schachner, A
通讯作者：
Schachner, A
影响因子：
3.4
作者：
FREMES, SE;LEVINTON, C;GOLDMAN, BS
通讯作者：
GOLDMAN, BS
影响因子：
6
作者：
Matsa, M;Paz, Y;Mohr, R
通讯作者：
Mohr, R
影响因子：
3.4
作者：
Taggart, DP
通讯作者：
Taggart, DP