Primary structure of cholera toxin beta-chain: a glycoprotein hormone analog?
Primary structure of cholera toxin beta-chain: a glycoprotein hormone analog?
复制标题
霍乱毒素β链的一级结构：糖蛋白激素类似物？
作者：
A. Kurosky;D. Markel;J. Peterson;W. Fitch
将霍乱毒素 β 链的完整序列（103 个氨基酸残基）与绒毛膜促性腺激素、促甲状腺激素、黄体生成素和卵泡刺激激素的 β 链进行比较。毒素β链与激素的总体化学相似性与随机结果没有统计学差异；然而，将毒素β链的前40个残基与糖蛋白激素进行比较，发现激素的一个片段在化学上非常相似。相似性纯属偶然的概率小于 0.003。
The completed sequence of the beta-chain of cholera toxin (103 amino acid residues) was compared to the beta-chains of chorionic gonadotropin, thyrotropin, luteinizing, and follicle stimulating hormones. The overall chemical similarity of the toxin beta-chain to the hormones was not statistically different from random; however, a comparison of the first 40 residues of the toxin beta-chain to the glycoprotein hormones revealed a segment of the hormones which was significantly chemically similar. The probability was less than .003 that the similarity was due to chance.