Organochlorine pesticides in serum and adipose tissue of pregnant women in Southern Spain giving birth by cesarean section
Organochlorine pesticides in serum and adipose tissue of pregnant women in Southern Spain giving birth by cesarean section
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DOI：
10.1016/j.scitotenv.2006.07.009
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发表时间：
2006-12-15
影响因子：
9.8
通讯作者：
Olea-Serrano, F.
中科院分区：
文献类型：
--
作者：
Jimenez Torres, M.;Campoy Folgoso, C.;Olea-Serrano, F.
自从滴滴涕出现以来，人们开发了越来越有效的杀虫剂，以克服昆虫对连续产品产生的抗药性。农药也用于公共卫生项目，以控制疾病媒介。尽管立法控制某些产品的使用，但它们一再出现在人类的脂肪组织、乳汁和血清中。本研究确定了剖腹产妇女的脂肪组织、血清和脐带中有机氯分子的存在，以建立这些生物区室之间有机氯分子含量的可能相关性，并检查胎儿暴露于具有激素效应的分子。GC/ECD检测到9种有机氯的存在，并通过GUMS确认。在脂肪组织和母体血清中，林丹、六氯苯、DDE、DDD和硫丹的浓度存在非常显著的差异（p < 0.000），但在硫丹II或硫丹硫酸盐的浓度方面没有显著差异（p > 0.5）。母体血清和脐带血清之间仅DDE浓度存在差异（p < 0.001）。在母体血清中观察到pp'DDE和op'DDT之间的关联（p < 0.094）。脂肪组织中pp'DDE和pp'DDD含量与脐带血有关，pp'DDT含量与母体血清有关。所获得的结果表明，当存在相对高浓度的农药时，可以仅在血清中测量接触量。(c)2006 Elsevier B. V.保留所有权利。
Since the appearance of DDT, increasingly potent insecticides have been developed to overcome the resistance developed by insects to successive products. Pesticides are also used in public health programs to control disease vectors. Despite legislation to control the use of certain products, they repeatedly appear in the adipose tissue, milk and serum of human populations. The present study determined the presence of organochlorine molecules in the adipose tissue, serum, and umblical cord of women giving birth by cesarean section in order to establish a possible correlation in organochlorine molecule content between these biological compartments and to examine fetal exposure to molecules with hormonal effects. Presence of nine organochlorines was detected by GC/ECD and confirmed by GUMS. Highly significant differences (p < 0.000) were observed between adipose tissue and maternal serum in concentrations of lindane, HCB, DDE, DDD, and endosulfan but not (p > 0.5) in concentrations of endosuffan II or endosulfan sulfate. Only DDE concentrations differed (p < 0.001) between maternal serum and umbilical cord serum. An association between pp'DDE and op'DDT was observed in maternal serum (p < 0.094). An association in pp'DDE and pp'DDD content was found between adipose tissue and umbilical cord serum, and in pp'DDT content between adipose tissue and maternal serum. Results obtained indicate that exposure can be measured solely in serum when relatively high concentrations of pesticides are present. (c) 2006 Elsevier B.V. All rights reserved.