Vertical vestibuloocular reflex in cat: asymmetry and adaptation.
Vertical vestibuloocular reflex in cat: asymmetry and adaptation.
复制标题
猫的垂直前庭眼反射：不对称和适应。
DOI：
10.1152/jn.1988.59.2.279
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发表时间：
1988
影响因子：
2.5
通讯作者：
King,WM
中科院分区：
文献类型：
--
作者：
Snyder,LH;King,WM
1.我们研究了眼速度在前2秒的垂直前庭眼反射（VOR）引起的猫放在他们的侧（90度滚转位置），并围绕地球垂直轴旋转。前庭刺激是在黑暗中提出的，由简短的梯形速度分布。用磁探测线圈记录眼球运动，并以高时间分辨率分析眼球运动速度。2.头旋转开始后的前2秒向上或向下的眼速度进行了表征和比较。然后诱导VOR增益（眼/头速度）的自适应变化，并再次比较向上和向下的眼速度响应。3.垂直VOR的早期时间过程是复杂的。在大约15 ms的潜伏期后，眼速度迅速增加，直到其大小相等且方向与头部速度相反。峰值眼速度在不到1秒内衰减到慢相眼速度（SPEV）的平台，约等于头部速度的-0.6倍。向上和向下的峰值眼速度是对称的。从峰值到平台的过渡对于向下VOR（向下的慢相）比对于向上VOR（向上的慢相）更快。通过向上SPEV获得的平台比通过向下SPEV获得的平台高约15%。4. VOR增益自适应是对称的。适应性向上眼速的百分比变化等于适应性向下眼速的百分比变化。峰值和平台期SPEV均适应，但峰值眼速度适应小于平台期眼速度。VOR潜伏期没有变化的适应。5. VOR对头部速度阶跃响应的轨迹可分为不变区间和变区间。不变间隔由眼运动的初始约15 ms组成。无论是头部运动的方向（向上与向下），也没有VOR增益的适应影响的眼睛运动轨迹在不变的时间间隔。变异间期在头部运动开始后约30 ms开始，在眼球运动开始后约15 ms开始。在不适应的动物，向下的眼睛速度超过向上的眼睛速度在变化的间隔。在适应的动物，眼速度在变化的时间间隔，但不是在不变的时间间隔，偏离眼速度在不适应的状态。我们认为，眼动反应轨迹的初始不变间隔（约15 ms）可能代表经典描述的三神经元弧的直接反应。（400字处截断摘要）
1. We studied eye velocity during the first 2 s of the vertical vestibuloocular reflex (VOR) elicited from cats placed on their sides (90 degrees roll position) and rotated about an earth vertical axis. Vestibular stimuli were presented in the dark and consisted of brief trapezoidal velocity profiles. Eye movements were recorded with a magnetic search coil, and eye velocity was analyzed with high temporal resolution. 2. The first 2 s of upward or downward eye velocity after the onset of head rotation was characterized and compared. Adaptive changes in VOR gain (eye/head velocity) were then induced, and upward and downward eye velocity responses were again compared. 3. The early time course of the vertical VOR was complex. After a latency of approximately 15 ms, eye velocity increased rapidly until it was equal in magnitude and opposite in direction to head velocity. The peak eye velocity decayed within less than 1 s to a plateau of slow-phase eye velocity (SPEV) equal to approximately -0.6 times the head velocity. Peak upward and downward eye velocity was symmetric. The transition from peak to plateau was more rapid for the downward VOR (slow phases downward) than for the upward VOR (slow phases upward). The plateau attained by upward SPEV was approximately 15% higher than the plateau attained by downward SPEV. 4. VOR gain adaptation was symmetric. The percentage change in adapted upward eye velocity equalled the percentage change in adapted downward eye velocity. Both peak and plateau SPEV adapted, but peak eye velocity adapted less than plateau eye velocity. VOR latency was unchanged by adaptation. 5. The trajectory of the VOR response to steps of head velocity could be divided into an invariant and a variant interval. The invariant interval consisted of the initial approximately 15 ms of the eye movement. Neither direction of head movement (upward vs. downward) nor adaptation of the VOR gain effected the eye movement trajectory during the invariant interval. The variant interval began approximately 30 ms after the onset of head movement and approximately 15 ms after the onset of eye movement. In unadapted animals, downward eye speed exceeded upward eye speed during the variant interval. In adapted animals, eye speed during the variant interval, but not during the invariant interval, diverged from eye speed in the unadapted state. We suggest that the initial invariant interval (approximately 15 ms) of the eye movement response trajectory may represent the direct response of the classically described three-neuron arc.(ABSTRACT TRUNCATED AT 400 WORDS)