Effects of the Activity of the Internal Globus Pallidus-Pedunculopontine Loop on the Transmission of the Subthalamic Nucleus-External Globus Pallidus-Pacemaker Oscillatory Activities to the Cortex
Effects of the Activity of the Internal Globus Pallidus-Pedunculopontine Loop on the Transmission of the Subthalamic Nucleus-External Globus Pallidus-Pacemaker Oscillatory Activities to the Cortex
复制标题
内苍白球-桥脚环活动对丘脑底核-外苍白球-起搏器振荡活动传递至皮质的影响
DOI：
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发表时间：
2004
影响因子：
1.2
通讯作者：
G. Shahidi
中科院分区：
文献类型：
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作者：
Arash Hadipour Niktarash;G. Shahidi
静止性震颤是特发性帕金森病最特异的体征。有人提出，帕金森震颤是由中枢振荡器的活动引起的。关于这种中枢振荡的可能原理，提出的假设之一是丘脑底核（STN）-苍白球外（GPe）-起搏器假说。中央振荡器的活动被认为通过跨皮质通路传输到外周。基于已知的 BG 解剖学和生理学，提出了基底神经节 (BG) 的计算模型，用于模拟内部苍白球 (GPi)-脚桥 (PPN) 环路活动对 STN-GPe-起搏器振荡活动传输到皮质的影响。根据模拟结果，GPi-PPN环路活动可以抑制STN-GPe-起搏器振荡活动向皮层的传递。这种抑制作用受多种因素控制，例如从 PPN 到 GPi 的突触连接强度、从 GPi 到 PPN 的突触连接强度、GPi 和 PPN 的自发强直活动、从 STN 到 PPN 的直接兴奋性投射、STN 振荡爆发活动的频率、STN 爆发的持续时间以及 I 型 PPN 神经元中的最大 T 型钙通道电导。
Resting tremor is the most specific sign for idiopathic Parkinson' disease. It has been proposed that parkinsonian tremor results from the activity of the central oscillators. One of the hypotheses, which have been proposed about the possible principles underlying such central oscillations, is the subthalamic nucleus (STN)-external globus pallidus (GPe)-pacemaker hypothesis. Activity from the central oscillator is proposed to be transmitted via trans-cortical pathways to the periphery. A computational model of the basal ganglia (BG) is proposed for simulating the effects of the internal globus pallidus (GPi)-pedunculopontine (PPN) loop activity on the transmission of the STN-GPe-pacemaker oscillatory activities to the cortex, based on known anatomy and physiology of the BG. According to the result of the simulation, the GPi-PPN loop activity can suppress the transmission of the STN-GPe-pacemaker oscillatory activities to the cortex. This suppressive effect is controlled by various factors such as the strength of the synaptic connection from the PPN to the GPi, the strength of the synaptic connection from the GPi to the PPN, the spontaneous tonic activities of the GPi and PPN, the direct excitatory projections from the STN to the PPN, the frequency of the STN oscillatory burst activity, the duration of the STN burst, and the maximum T-type calcium channel conductance in the type-I PPN neurons.
影响因子：
2.5
作者：
BERGMAN, H;WICHMANN, T;DELONG, MR
通讯作者：
DELONG, MR