Emerging Nanoporous Materials for Biomolecule Separation
Emerging Nanoporous Materials for Biomolecule Separation
复制标题
DOI：
10.1002/adfm.202113153
复制
发表时间：
2022-02
影响因子：
19
通讯作者：
Yongyang Song;Han Bao;Xinyi Shen;Xiuling Li;Xinmiao Liang;Shutao Wang
中科院分区：
文献类型：
--
作者：
Yongyang Song;Han Bao;Xinyi Shen;Xiuling Li;Xinmiao Liang;Shutao Wang
生物分子分离在从组学研究、结构分析、药物纯化到临床诊断的下游应用中起着至关重要的作用。在现有的生物分子分离材料和技术中，纳米多孔材料占据了主导地位。为了实现有效的生物分子分离，纳米多孔材料的界面总是用含有特定官能团的单层修饰。然而，由于目标生物分子丰度极低，高丰度背景生物分子的强烈干扰，化合物的相似特性，非特异性吸附等，单层修饰策略仍然遇到瓶颈。最近，几种新兴的纳米多孔材料，它们不需要单层修饰过程而制备，已被报道用于高效，高特异性和快速的生物分子分离。本文综述了近年来新兴的生物分子分离用纳米多孔材料，重点介绍了其不同于经典纳米多孔材料的设计原理和分离性能。本文首先讨论了单分子层修饰的经典设计策略，并介绍了这方面的最新进展。然后，新兴的纳米多孔材料超越单层修饰介绍。最后，展望了生物分子分离纳米多孔材料的发展前景、面临的挑战和广阔的应用前景。
Biomolecule separation plays a vital role in downstream applications ranging from omics research, structure analysis, and drug purification to clinical diagnosis. Among all existing materials and technologies towards biomolecule separation, nanoporous materials take the leading place. To achieve efficient biomolecule separation, the interface of nanoporous materials is always modified with a monolayer containing specific functional groups. However, the monolayer modification strategy still encounters bottlenecks due to extremely low abundance of target biomolecules, strong interference from high‐abundance background biomolecules, similar characteristics of compounds, unspecific adsorption, et al. Recently, several emerging nanoporous materials, which are prepared without the monolayer modification process, have been reported for high‐efficient, high‐specific, and rapid biomolecule separation. In this review, the authors summarize the emerging nanoporous materials for biomolecule separation, mainly focusing on the design principle and separation performance that are different from classical nanoporous materials. First, the classic design strategy of monolayer modification is discussed and the recent progress with this aspect is introduced. Then, emerging nanoporous materials beyond monolayer modification are introduced. At last, future developments, challenges, and great promise of biomolecule separation nanoporous materials are discussed.