Effects of Epidural Ketamine–Xylazine Combination on the Clinicophysiological and Haematobiochemical Parameters of Uraemic and Healthy Goats
Effects of Epidural Ketamine–Xylazine Combination on the Clinicophysiological and Haematobiochemical Parameters of Uraemic and Healthy Goats
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DOI：
10.1007/s11259-006-3367-4
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发表时间：
2007-02
影响因子：
2.2
通讯作者：
K. Singh;P. Kinjavdekar;Amarpal;H. Aithal;A. Gopinathan;G. Singh;A. Pawde;K. Pratap
中科院分区：
文献类型：
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作者：
K. Singh;P. Kinjavdekar;Amarpal;H. Aithal;A. Gopinathan;G. Singh;A. Pawde;K. Pratap
在尿毒症山羊和健康山羊的硬膜外给药后，评估了甲苯噻嗪-氯胺酮组合的有效性和安全性。将组合（赛拉嗪 0.025 mg/kg 和氯胺酮 2.5 mg/kg）给予尿毒症（n=6）和健康（n=6）动物的腰骶部硬膜外腔。从临床、生理、血液学和生化参数方面评估该组合。健康动物的镇痛起效快于尿毒症动物。赛拉嗪和氯胺酮对两组所有动物的尾部、会阴、腹股沟和大腿区域产生完全镇痛。然而，健康动物的完全镇痛持续时间比尿毒症动物更长。健康动物的共济失调程度高于尿毒症动物。两组的心率均显着下降；然而，呼吸频率和直肠温度没有显示任何显着变化。两组的血红蛋白、细胞压积和白细胞总数均无显着下降。尿毒症动物的白细胞总数明显较高。尿毒症动物的尿素氮和肌酐值显着升高。两组的血液电解质（Na+、K+和Cl−）和血气（Po2和Pco2）均未出现任何显着变化；然而，尿毒症动物的碱过剩明显较高。联合用药对不同系统产生的影响是短暂的，随着药物作用的减弱，其值会恢复正常。结果表明，在尿毒症山羊中硬膜外使用该组合可产生有效且安全的手术镇痛。
Xylazine–ketamine combination was evaluated for its efficacy and safety after epidural administration in uraemic and healthy goats. The combination (xylazine 0.025 mg/kg and ketamine 2.5 mg/kg) was administered to uraemic (n= 6) and healthy (n= 6) animals in the lumbosacral epidural space. The combination was evaluated in terms of clinical, physiological, haematological and biochemical parameters. The onset of analgesia was faster in healthy animals than in uraemic animals. Xylazine and ketamine produced complete analgesia of tail, perineum, inguinal and thigh regions in all animals of both groups. However, healthy animals showed longer duration of complete analgesia than did uraemic animals. Greater ataxia was recorded in healthy animals than in uraemic animals. The heart rate showed a significant decrease in both groups; however, respiratory rate and rectal temperature did not show any significant changes. Haemoglobin, packed cell volume and total leukocyte count decreased non-significantly in both groups. Total leukocyte count was significantly higher in uraemic animals. A significantly higher value of urea nitrogen and creatinine was recorded in uraemic animals. The blood electrolytes (Na+, K+and Cl−) and blood gases (Po2andPco2) did not show any significant changes in both groups; however, base excess was significantly higher in uraemic animals. The effects produced by the combination on different systems were transient and values normal as the effect of the drugs wore off. The results suggest that the combination when used epidurally in uraemic goats produced effective and safe surgical analgesia.