Retinal vascular caliber, cardiovascular risk factors, and inflammation: The Multi-Ethnic Study of Atherosclerosis (MESA)
Retinal vascular caliber, cardiovascular risk factors, and inflammation: The Multi-Ethnic Study of Atherosclerosis (MESA)
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DOI：
10.1167/iovs.05-1539
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发表时间：
2006-06-01
影响因子：
4.4
通讯作者：
Shahar, Eyal
中科院分区：
文献类型：
--
作者：
Wong, Tien Yin;Islam, F. M. Amirul;Shahar, Eyal
目的.在白人、黑人、西班牙裔和中国人的多种族人群中，描述视网膜小动脉和小静脉口径与心血管危险因素（包括炎症生物标志物）的关系。一项横断面研究，包括5979人年龄在45至84岁居住在美国六个社区。测量视网膜血管口径，并从数字视网膜照片中总结。标准心血管风险因素，包括炎症生物标志物（例如，高敏C反应蛋白[hsCRP]、白细胞介素[IL]-6和血浆纤维蛋白原）和内皮功能障碍（例如，测定血清可溶性细胞间粘附分子（sICAM）-1、纤溶酶原激活物抑制剂（派）-1水平。平均视网膜小动脉口径为144.1 ± 14.4（SD）μ m，小静脉口径为214.0 ± 22.2 μ m。在控制了年龄、性别、种族和中心的模型中，较小的视网膜小动脉口径与较高的收缩压和舒张压、高血压状态、当前饮酒、较高的体重指数和较高的总同型半胱氨酸水平有关;较大的视网膜小动脉口径与糖尿病、当前吸烟和较高的血浆纤维蛋白原水平有关;视网膜微静脉管径增大与糖尿病、吸烟、体重指数、腰臀比、高血糖、高甘油三酯、高密度脂蛋白胆固醇、高敏C反应蛋白、高纤维蛋白原、白细胞介素6、可溶性细胞间粘附分子1、纤溶酶原激活物抑制剂1、高密度脂蛋白胆固醇水平有关。在多变量分析中，黑人和西班牙裔的视网膜小动脉和小静脉口径比白人和中国人大。视网膜小动脉和小静脉口径与一系列心血管危险因素相关，包括高血压、糖尿病、肥胖和血脂异常。小静脉口径也与全身炎症有关。
PURPOSE. To describe the relationship of retinal arteriolar and venular caliber with cardiovascular risk factors, including inflammatory biomarkers, in a multiethnic population of whites, blacks, Hispanics, and Chinese.METHODS. A cross-sectional study comprising 5979 persons aged 45 to 84 years residing in six U.S. communities. Retinal vascular caliber was measured and summarized from digital retinal photographs. Standard cardiovascular risk factors, including biomarkers of inflammation (e.g., high-sensitivity C-reactive protein [hsCRP], interleukin [IL]-6, and plasma fibrinogen) and endothelial dysfunction (e.g., soluble intercellular adhesion molecule [sICAM]-1, plasminogen activator inhibitor [PAI]-1) were assessed.RESULTS. Mean retinal arteriolar caliber was 144.1 +/- 14.4 (SD) mu m, and venular caliber 214.0 +/- 22.2 mu m. In models controlling for age, gender, race-ethnicity, and center, smaller retinal arteriolar caliber was related to higher systolic and diastolic blood pressure, hypertension status, current alcohol consumption, greater body mass index, and higher levels of total homocysteine; larger retinal arteriolar caliber was related to diabetes, current cigarette smoking, and higher levels of plasma fibrinogen; and larger retinal venular caliber was related to diabetes, current cigarette smoking, greater body mass index and waist-hip ratio, higher levels of serum glucose, plasma triglyceride, plasma LDL-cholesterol, hsCRP, plasma fibrinogen, IL6, sICAM-1, and PAI-1 and lower levels of HDL-cholesterol. In multivariate analyses, blacks and Hispanics had larger retinal arteriolar and venular calibers than did whites and Chinese.CONCLUSIONS. Retinal arteriolar and venular caliber is associated with a range of cardiovascular risk factors, including hypertension, diabetes, measures of obesity, and dyslipidemia. Venular caliber is also associated with systemic inflammation.