Genetic mapping of complex traits.
Genetic mapping of complex traits.
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DOI：
10.1002/(sici)1097-0258(19991115)18:21
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发表时间：
1999-11
影响因子：
2
通讯作者：
Jane M. Olson;John S Witte;Robert C. Elston
中科院分区：
文献类型：
--
作者：
Jane M. Olson;John S Witte;Robert C. Elston
统计遗传作图方法是寻找导致复杂人类特征的基因的有力工具。定位方法结合了遗传的生物学机制知识和这些机制固有的随机性，以越来越精确地定位人类基因组上的性状基因。我们概述了两大类作图方法，遗传连锁分析和连锁不平衡分析，以及遗传的相关概念。
Statistical genetic mapping methods are powerful tools for finding genes that contribute to complex human traits. Mapping methods combine knowledge of the biological mechanisms of inheritance and the randomness inherent in those mechanisms to locate, with increasing precision, trait genes on the human genome. We provide an overview of the two major classes of mapping methods, genetic linkage analysis and linkage disequilibrium analysis, and related concepts of genetic inheritance.