Collagen fibrillogenesis in tendon development: Current models and regulation of fibril assembly
Collagen fibrillogenesis in tendon development: Current models and regulation of fibril assembly
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DOI：
10.1002/bdrc.20130
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发表时间：
2008-09-01
影响因子：
2.1
通讯作者：
Kuo, Catherine K.
中科院分区：
文献类型：
--
作者：
Banos, Charles C.;Thomas, Amelia H.;Kuo, Catherine K.
肌腱是基于胶原蛋白的纤维组织，用于连接肌肉并将力传递到骨骼。这些组织富含 I 型胶原蛋白，已被广泛研究以了解胶原纤维的形成。尽管其机制尚未完全阐明，但我们的理解不断取得进展。在这里，我们回顾了两种流行的胶原纤维生成模型，并讨论了候选细胞和细胞外基质分子对该过程的调节。尽管许多分子与胶原纤维生成的调节有关，但我们重点关注那些被认为与肌腱发育过程中 I 型胶原纤维形成特别相关的分子，包括胶原蛋白和富含亮氨酸的小蛋白聚糖家族的成员，以及其他分子，包括 scleraxis、软骨寡聚基质蛋白和细胞骨架蛋白。
Tendons are collagen-based fibrous tissues that connect and transmit forces from muscle to bone. These tissues, which are high in collagen type I content, have been studied extensively to understand collagen fibrillogenesis. Although the mechanisms have not been fully elucidated, our understanding has continued to progress. Here, we review two prevailing models of collagen fibrillogenesis and discuss the regulation of the process by candidate cellular and extracellular matrix molecules. Although numerous molecules have been implicated in the regulation of collagen fibrillogenesis, we focus on those that have been suggested to be particularly relevant to collagen type I fibril formation during tendon development, including members of the collagen and small leucine-rich proteoglycan families, as well as other molecules, including scleraxis, cartilage oligomeric matrix protein, and cytoskeletal proteins.