Copper-Catalyzed Decarboxylative Cyclization via Tandem C–P and C–N Bond Formation: Access to 2-Phosphorylmethyl Indoles
Copper-Catalyzed Decarboxylative Cyclization via Tandem C–P and C–N Bond Formation: Access to 2-Phosphorylmethyl Indoles
复制标题
通过串联 C-P 和 C-N 键形成的铜催化脱羧环化：获得 2-磷酰甲基吲哚
DOI：
10.1039/c8cc00739j
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发表时间：
--
影响因子：
4.9
通讯作者：
Lu Liang-Qiu
中科院分区：
文献类型：
--
作者：
Wang Bao-Cheng;Wang Ya-Ni;Zhang Mao-Mao;Xiao Wen-Jing;Lu Liang-Qiu
研究了一种新的铜催化乙炔基苯并恶嗪酮与P（O）H化合物的脱羧环合反应。该方法在温和条件下通过串联C-P/C-N键的形成，高效、高选择性地合成了一系列2-磷酰甲基吲哚，产率高达99%。
A novel copper-catalyzed decarboxylative cyclization of ethynyl benzoxazinanones with P(O)H compounds has been developed. This protocol leads to a series of 2-phosphorylmethyl indoles with high efficiency and selectivity (up to 99% yield) through tandem C–P/C–N bond formation under mild conditions.