Air pollution and seasonal asthma during the pollen season. A cohort study in Puertollano and Ciudad Real (Spain)
Air pollution and seasonal asthma during the pollen season. A cohort study in Puertollano and Ciudad Real (Spain)
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DOI：
10.1111/j.1398-9995.2007.01438.x
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发表时间：
2007-10-01
期刊：
影响因子：
12.4
通讯作者：
Alonso, A. M.
中科院分区：
文献类型：
--
作者：
Brito, F. Feo;Gimeno, P. Mur;Alonso, A. M.
背景：许多研究表明空气污染物与哮喘急诊之间存在正相关。然而，很少有研究包括花粉在分析这种关系时，在轻中度哮喘patients.Objective：要确定的重要性，如臭氧（O-3），颗粒（PM10），二氧化氮（NO2）和二氧化硫（SO2）的污染物，在临床过程中的轻中度花粉过敏性哮喘患者从两个西班牙城镇在拉曼恰：普埃尔托拉诺（高污染水平）和真实的城（低污染水平）。我们使用Poisson回归模型对来自Puertollano和Ciudad真实的两个花粉季节的137名患者进行了研究（2000-2001），分析空气污染物和花粉水平与日常症状、药物使用和峰流量测量的关系。Puertollano的哮喘症状数量和PM10、SO2和NO2水平的平均值高于Ciudad真实的。在Puertollano，当其值超过健康阈值时，PM 10滞后3天的哮喘风险增加6%，O-3滞后3天的哮喘风险增加8%，SO2滞后1天的哮喘风险增加4%，O-3滞后3天的哮喘风险增加15%（P < 0.05）。结论：普埃尔托拉诺的空气污染水平与花粉过敏性哮喘患者的哮喘症状风险增加有关，这与来自Ciudad真实的的类似人群一致。
Background: Many studies have demonstrated a positive association between air pollutants and emergency visits for asthma. However, few studies have included pollen when analysing this relationship in mild-moderate asthmatic patients.Objective: To determine the importance of the pollutants such as ozone (O-3), particles (PM10), nitrogen dioxide (NO2) and sulphur dioxide (SO2) in the clinical course of mild-moderate pollen-allergic asthmatic patients from two Spanish towns in La Mancha: Puertollano (high pollution levels) and Ciudad Real (low pollution levels).Methods: We used a Poisson regression model to study a cohort of 137 patients from Puertollano and Ciudad Real during two pollen seasons (2000-2001) and analysed the relationship between air pollutant and pollen levels and daily symptoms, the medication used and peak-flow measurements.Results: The number of asthma symptoms and the mean values of the PM10, SO2 and NO2 levels were higher in Puertollano than in Ciudad Real. In Puertollano, the risk of asthma increased by 6% with a 3-day lag for PM10, by 8% with a 3-day lag for O-3, by 4% with a 1-day lag for SO2 and by 15% with a 3-day lag for O-3 when its values exceeded the health threshold (P < 0.05). Conclusions: The air pollution levels in Puertollano were associated with an increased risk of asthma symptoms in pollen-allergic asthmatic patients com pared with a similar group from Ciudad Real.