Prostate cancer susceptibility and growth linked to Y chromosome genes.
Prostate cancer susceptibility and growth linked to Y chromosome genes.
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DOI：
10.2741/e830
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发表时间：
2018-03-01
期刊：
影响因子：
--
通讯作者：
Shukla S
中科院分区：
文献类型：
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作者：
Patel R;Khalifa AO;Isali I;Shukla S
Y染色体在前列腺癌进展和发病中的作用还不是很清楚。在46条染色体中，Y染色体决定了男性的性别。Y染色体比X染色体小，只有458个基因，而X染色体有2000多个基因。由于睾丸的高度氧化环境，Y染色体容易产生高突变率，仅在精子细胞中产生。Y染色体含有表观遗传信息，影响与前列腺癌发生和发展相关基因的表达。在这篇综述中，我们主要关注与Y染色体相关的遗传异常，可能与前列腺癌的发生和发展有关。
The role of Y chromosome in prostate cancer progression and incidence is not well known. Among the 46 chromosomes, Y chromosome determines the male gender. The Y chromosome is smaller than the X chromosome and contains only 458 genes compared to over 2000 genes found in the X chromosome. The Y chromosome is prone to high mutation rates, created exclusively in sperm cells due to the highly oxidative environment of the testis. Y chromosome harbors epigenetic information, which affects the expression of genes associated with the incidence and progression of prostate cancer. In this review, we focus on Y chromosome related genetic abnormalities, likely to be involved in the development and progression of prostate cancer.