Unconventional myosins acting unconventionally.
Unconventional myosins acting unconventionally.
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DOI：
10.1016/j.tcb.2009.03.003
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发表时间：
2009-06
影响因子：
19
通讯作者：
Bement WM
中科院分区：
文献类型：
--
作者：
Woolner S;Bement WM
非常规肌球蛋白是以atp调节的方式结合肌动蛋白丝的蛋白质。由于它们与膜相关，传统上认为它们是主要沿着肌动蛋白丝运输膜细胞器的马达。然而，最近发现了肌凝蛋白的许多与细胞器运输不明显相关的作用，包括组织f -肌动蛋白，有丝分裂纺锤体调节和基因转录。此外，很明显，不同肌凝蛋白的运动结构域在其生物物理特性上有显著差异。我们认为，大多数非常规肌凝蛋白主要作为细胞器转运蛋白的假设可能是错误的。
Unconventional myosins are proteins that bind actin filaments in an ATP-regulated manner. Because of their association with membranes, they have traditionally been viewed as motors that function primarily to transport membranous organelles along actin filaments. Recently, however, a wealth of roles for myosins that are not obviously related to organelle transport have been uncovered, including organization of F-actin, mitotic spindle regulation and gene transcription. Furthermore, it has also become apparent that the motor domains of different myosins vary strikingly in their biophysical attributes. We suggest that the assumption that most unconventional myosins function primarily as organelle transporters might be misguided.