Butyrate and colonic cytokinetics: differences between in vitro and in vivo studies.
Butyrate and colonic cytokinetics: differences between in vitro and in vivo studies.
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DOI：
10.1097/00008469-199510000-00007
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发表时间：
1995-10
期刊：
影响因子：
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通讯作者：
J. Lupton
中科院分区：
文献类型：
--
作者：
J. Lupton
目前的理论是丁酸盐通过抑制结肠细胞增殖和促进分化以及可能的凋亡来保护结肠癌。这一理论的一个延伸是，膳食纤维可以通过结肠微生物群产生丁酸来预防结肠癌。这些概念的支持来自几个来源，但试图将各种推理结合在一个连贯的模式中，会发现许多不一致之处。本综述的目的是澄清导致丁酸盐对结肠癌具有保护作用以及纤维通过产生丁酸盐具有保护作用的结论的证据链。将提供支持或不支持这一推理过程中每一步的数据，并在存在不一致之处予以说明。
A current theory is that butyrate protects against colon cancer by inhibiting colonic cell proliferation and promoting differentiation and perhaps apoptosis. An extension of this theory is that dietary fibre may protect against colon cancer through the production of butyrate by the colonic microflora. Support for these concepts comes from several sources, but an attempt to bring the various lines of reasoning together in one cohesive pattern reveals a number of inconsistencies. The purpose of this review is to clarify the chain of evidence that results in the conclusion that butyrate is protective against colon cancer and that fibre is protective through the production of butyrate. Data will be presented that support or fail to support each step in this reasoning process and inconsistencies will be noted where they exist.