Gut microbiota composition correlates with diet and health in the elderly
Gut microbiota composition correlates with diet and health in the elderly
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DOI：
10.1038/nature11319
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发表时间：
2012-08-09
期刊：
影响因子：
64.8
通讯作者：
O'Toole, Paul W.
中科院分区：
文献类型：
--
作者：
Claesson, Marcus J.;Jeffery, Ian B.;O'Toole, Paul W.
肠道微生物群组成的改变与几种慢性疾病有关，包括肥胖和炎性疾病。老年人的微生物群显示出比年轻人更大的个体间差异。在这里，我们表明，来自178名老年受试者的粪便微生物群组成形成了群体，与社区，日间医院，康复或长期住宿护理的居住位置相关。然而，通过饮食对受试者进行聚类，可以通过相同的居住地点和微生物群分组将他们分开。微生物群组成的分离与虚弱、共病、营养状态、炎症标志物的测量以及粪便水中的代谢物显著相关。长期护理人员的个体微生物群多样性明显低于社区居民。社区相关微生物群的丧失与虚弱程度的增加相关。总的来说，这些数据支持饮食，微生物群和健康状况之间的关系，并表明饮食驱动的微生物群改变在衰老时不同的健康下降率中的作用。
Alterations in intestinal microbiota composition are associated with several chronic conditions, including obesity and inflammatory diseases. The microbiota of older people displays greater inter-individual variation than that of younger adults. Here we show that the faecal microbiota composition from 178 elderly subjects formed groups, correlating with residence location in the community, day-hospital, rehabilitation or in long-term residential care. However, clustering of subjects by diet separated them by the same residence location and microbiota groupings. The separation of microbiota composition significantly correlated with measures of frailty, co-morbidity, nutritional status, markers of inflammation and with metabolites in faecal water. The individual microbiota of people in long-stay care was significantly less diverse than that of community dwellers. Loss of community-associated microbiota correlated with increased frailty. Collectively, the data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing.