A novel tumor and mitochondria dual-targeted photosensitizer showing ultra-efficient photodynamic anticancer activities
A novel tumor and mitochondria dual-targeted photosensitizer showing ultra-efficient photodynamic anticancer activities
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一种新型肿瘤和线粒体双靶向光敏剂显示出超高效的光动力抗癌活性
DOI：
10.1039/c8cc09456j
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发表时间：
2019
影响因子：
4.9
通讯作者：
Xue Jinping
中科院分区：
文献类型：
--
作者：
Zhao Xuan;Huang Yuchao;Yuan Gankun;Zuo Ke;Huang Yafan;Chen Juanjuan;Li Jinyu;Xue Jinping
我们设计并合成了一种简单而高效的光敏剂（G-Mito-Pc），它可以精确地靶向表皮生长因子受体（EGFR）过表达的癌细胞的线粒体，以实现在细胞和细胞器水平上的双重靶向功能。我们进一步探讨了可能的分子机制的增强生物活性的G-Mito-Pc相比，使用分子动力学模拟与生理相关的线粒体膜模型的相互作用的参考光敏剂。
We designed and synthesized a simple, but highly effective photosensitizer (G-Mito-Pc), which can precisely target the mitochondria of epidermal growth factor receptor (EGFR)-overexpressing cancer cells, to achieve dual targeting function at both cell and organelle levels in cancer therapy. We further explored the possible molecular mechanism of the enhanced bioactivity of G-Mito-Pc compared to that of the reference photosensitizer using molecular dynamics simulations on their interactions with a physiologically relevant mitochondrial membrane model.