Polydopamine-Assisted Immobilization of Copper Ions onto Hemodialysis Membranes for Antimicrobial
Polydopamine-Assisted Immobilization of Copper Ions onto Hemodialysis Membranes for Antimicrobial
复制标题
聚多巴胺辅助将铜离子固定到血液透析膜上以实现抗菌
DOI：
10.1021/acsabm.8b00106
复制
发表时间：
2018
影响因子：
4.7
通讯作者：
Ning Chengyun
中科院分区：
文献类型：
--
作者：
Xing Jun;Wang Qiyou;He Tianrui;Zhou Zhengnan;Chen Dafu;Yi Xin;Wang Zhengao;Wang Renxian;Tan Guoxin;Yu Peng;Ning Chengyun
血液透析治疗是终末期肾病（ESRD）患者延长生命的主要治疗方法。为了减少血液透析治疗过程中的致病性感染，将贻贝激发的聚多巴胺（PDA）自聚合到聚醚砜（PES）膜上，以固定铜离子，因为PDA涂层可以牢固地附着在聚醚砜（PES）膜上，并利用其官能团固定抗菌金属离子。通过PDA固定的铜离子可以深入PES膜孔的内表面。透水性试验进一步表明，PDA涂层能明显增强PES膜的亲水性。铜离子固定化PES膜具有较好的抗菌活性，且铜离子释放量相对安全（低于1 ppm）。此外，溶血试验结果显示，与纯PES膜相比，pda辅助抗菌PES膜可以减轻红细胞损伤。综上所述，通过pda辅助铜离子固定化PES血液透析膜获得抗菌能力，可减少抗生素的滥用，有利于肾脏疾病患者。
The hemodialysis therapy is the primary treatment for the end-stage renal disease (ESRD) patients to extend their lives. To reduce the pathogenic infection during hemodialysis treatment, mussel-inspired polydopamine (PDA) was self-polymerized onto poly(ether sulfone) (PES) membranes to immobilize copper ions, because PDA coating could firmly adhere to the PES membranes and immobilize antimicrobial metal ions with its functional groups. The immobilized copper ions through PDA can penetrate deeply into the inner surface of the pores of PES membrane. Water permeability test further indicates PDA coating can obviously enhance the hydrophilicity of PES membranes. And copper ion immobilized PES membranes showed effective antibacterial activity with a relative safe release amount of copper ions (below 1 ppm). Furthermore, hemolysis test results revealed that PDA-assisted antibacterial PES membranes can relieve red blood cells damage compared to the pure PES membranes. To sum up, PES hemodialysis membranes obtained the antibacterial ability by the PDA-assisted copper ion immobilization, which can reduce the abuse of antibiotics and is beneficial to the patient suffering from kidney disease.