Diuretic Properties and Chemical Constituent Studies on Stauntonia brachyanthera.
Diuretic Properties and Chemical Constituent Studies on Stauntonia brachyanthera.
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野木瓜的利尿作用及化学成分研究
DOI：
10.1155/2015/432419
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Meng da L
中科院分区：
文献类型：
--
作者：
Liu XL;Wang DD;Wang ZH;Meng da L
药理学评价表明，与呋塞米处理组相比，短叶菊茎提取物可显著增加大鼠的尿量，且作用持续时间更长。最好的效果出现在前两个小时，科学地证实了植物的利尿作用。比较生药学研究表明，短叶菊茎的生药特征与阿克比亚茎相似。通过色谱分析和核磁共振分析，分离得到10个三萜、6个黄酮类化合物、4个木脂素和3个苯乙醇苷类化合物，其结构类型与奎纳塔属植物非常相似。其中7个化合物为首次在石桐属植物中发现，其中钙根苷B是两种植物的共同特征成分。从其相似的生药学特征、药理作用和化学成分可以得出结论，认为短叶菊极有可能成为近年来供应极为短缺的蛇麻的继任者。
The pharmacological evaluation demonstrated that the extracts from the stem of S. brachyanthera could significantly increase the outputs of urine of rats compared to those of furosemide treated group, and the effect could last for a longer period of time. The best effect appeared in the first two hours, which scientifically confirmed the diuretic effect of the plant. The comparative pharmacognosy study showed that the characters of the crude drugs of the stem of S. brachyanthera were similar to those of Akebia caulis. Further systemic work on its chemical constituents by chromatographic methods and NMR elucidations led to the isolation of 10 triterpenoids, 6 flavonoids, 4 lignanoids, and 3 phenylethanoid glycosides, whose structural types were much similar to those of A. quinata. Among them, 7 compounds were firstly reported in the genus of Stauntonia and calceolarioside B was the common characteristic constituent in both plants. From the similar pharmacognosy characters, pharmacological effects, and chemical constituents, it could be concluded that S. brachyanthera have a great possibility to be a succedaneum of Akebia caulis, whose supply is extremely short in recent years.