Untreated HIV infection is associated with higher blood alcohol levels.
Untreated HIV infection is associated with higher blood alcohol levels.
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未经治疗的艾滋病毒感染与较高的血液酒精浓度有关。
DOI：
10.1097/qai.0b013e318256625f
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Rainey,PetrieM
中科院分区：
文献类型：
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作者：
McCance-Katz,ElinoreF;Lum,PaulaJ;Beatty,George;Gruber,ValerieA;Peters,Marion;Rainey,PetrieM
背景：酒精滥用与HIV/AIDS进展有关，但HIV感染和治疗对酒精暴露的影响迄今尚未探讨。本试点研究探讨未经治疗的HIV感染的血液酒精浓度（BAC）相对BAC后开始的抗逆转录病毒疗法（ART）。方法：15名志愿者与未经治疗的HIV/AIDS参加了2套酒精或酒精安慰剂管理研究开始前和开始后的ART。口服酒精（1 g/kg）或酒精安慰剂管理，参与者被随访的药代动力学，主观反应，和认知效果超过8小时。在最初的酒精研究后，由参与临床医生选择的ART方案开始实施。观察ART给药至少2周。然后，参与者返回第二组酒精/安慰剂管理研究，而对ART。结果：参与者有显着较高的BAC（P< 0.001）ART前比ART管理后。未经治疗的HIV患者的酒精曲线下面积显著更高（P= 0.011），Cmax（P= 0.015）和C min（P= 0.05）显著更高。ART前和ART后的消除率没有差异。尽管下降后，BAC ART启动，主观反应没有差异，观察到酒精administration.Conclusions：未经治疗的HIV感染与较高的BAC比ART后观察到的风险。这些研究结果表明，未经治疗的HIV疾病的患者摄入酒精的风险更大的酒精相关的不良事件和毒性，并强调需要同时治疗酒精使用障碍和艾滋病病毒的患者共同发生的条件。
Background:Alcohol abuse has been associated with HIV/AIDS progression, but the effects of HIV infection and treatment on alcohol exposure have not been explored to date. This pilot study examines the relationship of untreated HIV infection to blood alcohol concentrations (BAC) relative to BAC after initiation of antiretroviral therapy (ART).Methods:Fifteen volunteers with untreated HIV/AIDS participated in 2 sets of alcohol or alcohol placebo administration studies before and after initiation of ART. Oral alcohol (1 g/kg) or alcohol placebo was administered, participants were followed for pharmacokinetics, subjective responses, and cognitive effects over 8 hours. After initial alcohol studies, the ART regimen selected by participant clinicians was instituted. Observed ART dosing took place for at least 2 weeks. Participants then returned for a second set of alcohol/placebo administration studies while on ART.Results:Participants had significantly higher BAC (P< 0.001) before ART than after ART administration. Alcohol area under the curve was significantly higher in untreated HIV disease (P= 0.011) with significantly higher C max (P= 0.015) and C min (P= 0.05). The elimination rate was not different between pre-ART and post-ART conditions. Despite declines in BAC after ART initiation, no differences in subjective responses were observed with alcohol administration.Conclusions:Untreated HIV infection is associated with risk for higher BAC than that observed after ART. These findings indicate that patients with untreated HIV disease who ingest alcohol are at greater risk for alcohol associated adverse events and toxicities and underscores the need for simultaneous treatment of alcohol use disorders and HIV in patients with co-occurring conditions.