Tuberculosis in Pregnant and Postpartum Women: Epidemiology, Management, and Research Gaps
Tuberculosis in Pregnant and Postpartum Women: Epidemiology, Management, and Research Gaps
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DOI：
10.1093/cid/cis732
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发表时间：
2012-12-01
影响因子：
11.8
通讯作者：
Gupta, Amita
中科院分区：
文献类型：
--
作者：
Mathad, Jyoti S.;Gupta, Amita
结核病在妇女生育期最为常见，是母婴死亡的主要原因。由于数据不足，各国的筛查和管理准则差别很大。在这篇文章中，我们回顾了以下方面的现有数据：（1）育龄妇女结核病的全球负担;（2）妊娠期和产后期如何影响结核病的病程;（3）如何筛查和诊断妊娠期和产后妇女的活动性和潜伏性结核病;（4）妊娠期和产后期间活动性和潜伏性结核病的管理，包括结核病药物的安全性;（5）婴儿结局。我们还包括艾滋病毒/结核病合并感染和耐药结核病的数据。最后，我们强调在结核病的研究差距在孕妇和产后妇女。
Tuberculosis is most common during a woman's reproductive years and is a major cause of maternal-child mortality. National guidelines for screening and management vary widely owing to insufficient data. In this article, we review the available data on (1) the global burden of tuberculosis in women of reproductive age; (2) how pregnancy and the postpartum period affect the course of tuberculosis; (3) how to screen and diagnose pregnant and postpartum women for active and latent tuberculosis; (4) the management of active and latent tuberculosis in pregnancy and the postpartum period, including the safety of tuberculosis medications; and (5) infant outcomes. We also include data on HIV/tuberculosis coinfection and drug-resistant tuberculosis. Finally, we highlight research gaps in tuberculosis in pregnant and postpartum women.