Do peripartum and postmenopausal women with primary liver cancer have a worse prognosis? A nationwide cohort in Taiwan.
Do peripartum and postmenopausal women with primary liver cancer have a worse prognosis? A nationwide cohort in Taiwan.
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DOI：
10.4254/wjh.v13.i11.1766
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发表时间：
2021-11-27
影响因子：
2.4
通讯作者：
Lai HC
中科院分区：
文献类型：
--
作者：
Tseng GW;Lin MC;Lai SW;Peng CY;Chuang PH;Su WP;Kao JT;Lai HC
虽然原发性肝癌 (PLC) 是世界上最常见的癌症之一，但很少有大规模人群研究评估围产期和绝经后患有 PLC 的女性的临床生存结果。旨在调查患有 PLC 的围产期和绝经后妇女与未围产期和绝经后的妇女相比，其总体生存率是否较低。本倾向得分匹配研究使用了 2000 年至 2012 年台湾国民健康保险索赔数据。纳入了 40 名患有 PLC 的围产期女性的队列和由 160 名未患有围产期的女性组成的参考队列。在患有/未绝经的 PLC 女性研究中，纳入了由 10752 名患有 PLC 的绝经女性组成的研究队列和由 2688 名未绝经的女性组成的对照组。与非围产期队列相比，围产期 PLC 患者的死亡风险不显着 [调整后风险比 (aHR) = 1.40，95% 置信区间 (CI)：0.89-2.20，P = 0.149]。围产期PLC患者与非围产期队列患者不同随访时长的生存率无显着差异。与50岁或以上（绝经后）诊断为PLC的患者相比，年龄小于50岁（未绝经）诊断为PLC的患者的死亡风险显着降低（aHR = 0.64，95％CI：0.61-0.68，P < 0.001）。当随访时间分别为0.5年（72.44% vs 64.16%）、1年（60.57% vs 51.66%）、3年（42.92% vs 31.28%）和5年（37.02% vs 21.83%）时，<50岁的PLC女性的生存率显着高于老年PLC女性（P < 0.001）。患有PLC的围产期女性与没有围产期的女性相比，生存率没有差异。与未绝经的患者相比，患有 PLC 的绝经女性的生存率较差。
While primary liver cancer (PLC) is one of the most common cancers around the world, few large-scale population-based studies have been reported that evaluated the clinical survival outcomes among peripartum and postmenopausal women with PLC. To investigate whether peripartum and postmenopausal women with PLC have lower overall survival rates compared with women who were not peripartum and postmenopausal. The Taiwan National Health Insurance claims data from 2000 to 2012 was used for this propensity-score-matched study. A cohort of 40 peripartum women with PLC and a reference cohort of 160 women without peripartum were enrolled. In the women with PLC with/without menopause study, a study cohort of 10752 menopausal females with PLC and a comparison cohort of 2688 women without menopause were enrolled. Patients with peripartum PLC had a non-significant risk of death compared with the non-peripartum cohort [adjusted hazard ratios (aHR) = 1.40, 95% confidence intervals (CI): 0.89-2.20, P = 0.149]. The survival rate at different follow-up durations between peripartum PLC patients and those in the non-peripartum cohort showed a non-significant difference. Patients who were diagnosed with PLC younger than 50 years old (without menopause) had a significant lower risk of death compared with patients diagnosed with PLC at or older than 50 years (postmenopausal) (aHR = 0.64, 95%CI: 0.61-0.68, P < 0.001). The survival rate of women < 50 years with PLC was significantly higher than older women with PLC when followed for 0.5 (72.44% vs 64.16%), 1 (60.57% vs 51.66%), 3 (42.92% vs 31.28%), and 5 year(s) (37.02% vs 21.83%), respectively (P < 0.001). Peripartum females with PLC have no difference in survival rates compared with those patients without peripartum. Menopausal females with PLC have worse survival rates compared with those patients without menopause.
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DOI：
10.1034/j.1600-0676.2001.210507.x
发表时间：
2001-10-01
期刊：
LIVER
影响因子：
--
作者：
Shimizu, I;Inoue, H;Ito, S
通讯作者：
Ito, S
影响因子：
0.6
作者：
Li AJ;Zhou WP;Lu JH;Cui LJ;Yang XY;Yin L;Wu MC
通讯作者：
Wu MC
影响因子：
0.8
作者：
Matsuo M;Furukawa K;Shimizu H;Yoshitomi H;Takayashiki T;Kuboki S;Takano S;Suzuki D;Sakai N;Kagawa S;Nojima H;Ohsuka M
通讯作者：
Ohsuka M
影响因子：
4.7
作者：
Lee, Sang R.;Lee, Young Ho;Hong, Eui-Ju
通讯作者：
Hong, Eui-Ju
影响因子：
13.8
作者：
Lin, Longfei;Yan, Lei;Li, Hui
通讯作者：
Li, Hui