Genetic models of schizophrenia and bipolar disorder -: Overlapping inheritance or discrete genotypes?
Genetic models of schizophrenia and bipolar disorder -: Overlapping inheritance or discrete genotypes?
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DOI：
10.1007/s00406-005-0583-9
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发表时间：
2005-06-01
影响因子：
4.7
通讯作者：
Rietschel, M
中科院分区：
文献类型：
--
作者：
Maier, W;Höfgen, B;Rietschel, M
精神分裂症和情感性障碍一直被认为是病理科和病因学上不同的疾病。这一假设受到新的生物学研究进展的挑战。这两种疾病都受遗传因素的强烈影响；因此，基因研究是这一讨论的主要贡献者。我们回顾了目前关于精神分裂症和情感障碍（主要是双相情感障碍）之间遗传关系的证据（各种遗传研究方法已特别应用于双相情感障碍）。最近的家庭和双胞胎研究表明，两种疾病之间的共分离性越来越一致，由于基础率低，很难确定地发现。对影响两种疾病的特定基因进行系统的分子遗传学搜索，现在已经确定了一种显然与两种疾病有关的基因（G72/G30）；其他候选基因显示出一些证据，显示为易感基因，对两种疾病都有非常温和的影响，尽管不是一致的（例如，COMT， BDNF）。考虑到连锁研究中出现的精神分裂症候选区域和双相情感障碍候选区域之间的重叠，还有空间推测其他常见的易感基因。
Schizophrenia and affective disorder have been considered to be nosologically and etiologically distinct disorders. This postulate is challenged by progress in new biological research. Both disorders are strongly influenced by genetic factors; thus genetic research is a main contributor to this discussion. We review current evidence of the genetic relationship between schizophrenia and affective disorders, mainly bipolar disorder (the various genetic research methods have been particularly applied to bipolar disorder). Recent family and twin studies reveal a growing consistency in demonstrating cosegregation between both disorders which is difficult to detect with certainty given the low base rates. Systematic molecular genetic search for specific genes impacting on either disorder has now identified one gene which is apparently involved in both disorders (G72/G30); other candidate genes reveal some evidence to present as susceptibility genes with very modest effects for each of both disorders, although not consistently so (e. g., COMT, BDNF). There is room for speculation about other common susceptibility genes, given the overlap between candidate regions for schizophrenia and those for bipolar disorder emerging from linkage studies.