Personality traits in bipolar disorder and influence on outcome.
Personality traits in bipolar disorder and influence on outcome.
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DOI：
10.1186/s12888-017-1332-0
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发表时间：
2017-05-03
期刊：
影响因子：
4.4
通讯作者：
Landén M
中科院分区：
文献类型：
--
作者：
Sparding T;Pålsson E;Joas E;Hansen S;Landén M
本研究的目的是调查双相情感障碍I型和II型以及健康对照者的人格特征，并研究人格是否影响双相情感障碍的病程。110例双相情感障碍I型患者、85例双相情感障碍II型患者和86例健康个体的人格特征使用瑞典大学人格量表（SSP）进行评估，SSP是一种旨在探索人格相关脆弱性和精神疾病相关性的工具。患者前瞻性随访2年。为了评估神经质、攻击性和去抑制对病程的影响，我们对结果变量情绪发作（抑郁、低躁狂/躁狂、混合型）、自杀企图、暴力和病假天数进行了logistic回归。与健康对照组相比，双相情感障碍I型和II型表现出更高的神经质，攻击性和去抑制的全球措施。三分之一的患者在总体神经质测量中得分高于基于人群的标准平均值≥1 SD。然而，双相情感障碍的两种亚型在所有人格特征上都无法区分。在未校正的模型中，基线时较高的神经质预测未来的抑郁发作和自杀企图/暴力行为，但当根据MADRS评估的基线抑郁症状进行校正时，这种关联消失。显著少数患者的神经质、攻击性和去抑制性总体指标评分高于人群平均值≥1 SD;如此高的评分通常在临床上很明显。然而，在2年的时间内，人格特征似乎没有预测价值。
The aim was to investigate the personality profile of bipolar disorder I and II, and healthy controls, and to study whether personality influences the course of bipolar disorder. One hundred ten patients with bipolar disorder I, 85 patients with bipolar disorder II, and 86 healthy individuals had their personality profile assessed using the Swedish universities Scales of Personality (SSP), an instrument developed to explore personality-related vulnerabilities and correlates of psychiatric disorders. Patients were followed prospectively for 2 years. To assess the impact of Neuroticism, Aggressiveness, and Disinhibition on illness course, we performed logistic regressions with the outcome variables mood episodes (depressive, hypo/manic, mixed), suicide attempts, violence, and the number of sick leave days. Bipolar disorder I and II demonstrated higher global measures of Neuroticism, Aggressiveness, and Disinhibition as compared with healthy controls. A third of the patients scored ≥1 SD above the population-based normative mean on the global neuroticism measure. The two subtypes of bipolar disorder were, however, undistinguishable on all of the personality traits. In the unadjusted model, higher neuroticism at baseline predicted future depressive episodes and suicide attempts/violent behavior, but this association disappeared when adjusting for baseline depressive symptoms as assessed with MADRS. A significant minority of the patients scored ≥1 SD above the population mean on the global measures of Neuroticism, Aggressiveness and Disinhibition; scores this high are usually evident clinically. Yet, the personality profile does not seem to have prognostic value over a 2-year period.