Electrical Stimulation of the Cochlea to Reduce Tinnitus.
Electrical Stimulation of the Cochlea to Reduce Tinnitus.
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电刺激耳蜗以减少耳鸣。
DOI：
10.1055/s-0028-1095892
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发表时间：
2008-11
影响因子：
--
通讯作者：
Coelho C
中科院分区：
文献类型：
--
作者：
Tyler RS;Rubinstein J;Pan T;Chang SA;Gogel SA;Gehringer A;Coelho C
本文综述了耳鸣可能的神经相关因素，包括频率增加、频率减少、周期性活动、神经元间的同步活动以及活跃和不活跃神经元之间的边缘。我们对电流如何改变这些神经活动模式提出了一些建议。例如，如果耳鸣表现为周期性的神经活动，那么电刺激就需要破坏这种周期性。本文回顾了一些耳蜗电刺激的病例，表明耳鸣可以减少或消除，尽管耳蜗电刺激因人而异。最后，在总结了一些关键的观察结果后，我们提出了一些下一步将其带入临床应用的建议。
This article reviews possible neural correlates of tinnitus, including an increase in rate, a decrease in rate, periodic activity, synchronous activity across neurons, and an edge between active and inactive neurons. We make some suggestions regarding how electrical current might alter these patterns of neural activity. For example, if tinnitus were represented with periodic neural activity, then electrical stimulation would need to disrupt this periodicity. Some cases of cochlear electrical stimulation are reviewed that show the tinnitus can be reduced or eliminated with cochlear electrical stimulation although it varies across individuals. Finally, after summarizing some key observations, we suggest some next steps to bring this into a clinical application.