Enhancing children's cognitive function and achievement through carotenoid consumption: The Integrated Childhood Ocular Nutrition Study (iCONS) protocol.
Enhancing children's cognitive function and achievement through carotenoid consumption: The Integrated Childhood Ocular Nutrition Study (iCONS) protocol.
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通过摄入类胡萝卜素增强儿童的认知功能和成就：综合儿童眼部营养研究（iCONS）方案。
DOI：
10.1016/j.cct.2022.106964
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发表时间：
2022
影响因子：
2.2
通讯作者：
Khan,NaimanA
中科院分区：
文献类型：
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作者：
Cannavale,CorinneN;Keye,ShelbyA;Rosok,Laura;Martell,Shelby;Holthaus,ToriA;Reeser,Ginger;Raine,LaurenB;Mullen,SeanP;Cohen,NealJ;Hillman,CharlesH;Hammond,BillyR;Renzi-Hammond,Lisa;Khan,NaimanA
叶黄素和玉米黄质（L + Z）是类胡萝卜素，积累在神经组织中，并可能赋予认知的好处。虽然横断面研究揭示了黄斑类胡萝卜素（MC）和认知之间的正相关，但没有研究调查L + Z补充剂是否会影响儿童时期的MC和认知。因此，儿童眼营养综合研究旨在调查9个月以上L + Z补充剂对青春期前儿童的学习能力、注意力控制、记忆力和MC的影响。8-10岁儿童（N= 288）将入组一项为期9个月的双盲、安慰剂对照、随机试验。该研究已在美国国家医学图书馆http://ClinicalTrials.gov注册中心注册并批准为临床试验（NCT 05177679）。参与者将被随机分配到活性（10 mg叶黄素+2 mg玉米黄质）或候补安慰剂对照组。主要结果包括分别使用空间重建任务、埃里克森侧翼任务和考夫曼学业和教育成就测试第3版的露营依赖性记忆、注意力抑制和学业成就。次要结果包括注意力资源分配和信息处理速度的事件相关脑电位（即，P3/P300振幅和潜伏期）。将使用异色闪烁光度法评估黄斑色素光密度（MPOD）。认知评估将在补充期完成之前和之后完成。MPOD将在补充期之前、中点（4-5个月）和之后（9个月）进行量化。据推测，L + Z补充剂将改善认知和学业成绩。此外，认知和成就的益处预计将通过治疗组参与者中MC的增加来介导。
Lutein and zeaxanthin (L + Z) are carotenoids that accumulate in neural tissue and potentially confer benefits to cognition. Whereas cross-sectional studies have revealed positive associations between macular carotenoids (MC) and cognition, no studies have investigated whether L + Z supplementation impacts MC and cognition in childhood. Accordingly, the Integrated Childhood Ocular Nutrition Study aims to investigate the impact of L + Z supplementation over 9-months on academic abilities, attentional control, memory, and MC among preadolescent children. Children 8–10 years (N= 288) will enroll in a 9-month double-blind, placebo-controlled, randomized trial. The study is registered and approved as a clinical trial on the U.S. National Library of Medicine http://ClinicalTrials.gov registry (NCT05177679). Participants will be randomized into an active (10 mg lutein+2 mg zeaxanthin) or waitlist placebo-controlled group. Primary outcomes include hippocampal-dependent memory, attentional inhibition, and academic achievement using a spatial reconstruction task, an Eriksen flanker task, and the Kaufman Test of Academic and Educational Achievement 3rd edition, respectively. Secondary outcomes include event-related brain potentials of attentional resource allocation and information processing speed (i.e., P3/P300 amplitude and latency) recorded during the flanker task. Macular pigment optical density (MPOD) will be assessed using heterochromatic flicker photometry. Cognitive assessments will be completed prior to and after completion of the supplementation period. MPOD will be quantified prior to, at the mid-point of (4–5 months), and after (9 months) the supplementation period. It is hypothesized that L + Z supplementation will improve cognition and academic achievement. Further, benefits for cognition and achievement are anticipated to be mediated by increases in MC among treatment group participants.