Cerebrospinal fluid penetration of active metabolites of cyclophosphamide and ifosfamide in rhesus monkeys.
Cerebrospinal fluid penetration of active metabolites of cyclophosphamide and ifosfamide in rhesus monkeys.
复制标题
环磷酰胺和异环磷酰胺活性代谢物在恒河猴中的脑脊液渗透。
作者：
C. Arndt;F. Balis;C. McCully;O. Colvin;D. Poplack
The penetration of the active metabolites of cyclophosphamide (CP) and ifosfamide (IF) into cerebrospinal fluid (CSF) was determined in rhesus monkeys following an i.v. infusion of 1 gm/m2 of CP and IF. Active metabolites were measured using a high-performance liquid chromatography assay with fluorometric detection following derivatization with m-aminophenol. CSF to blood ratios of the active metabolites of CP and IF were found to be 0.17 and 0.13 following systemic dosing of CP and IF, respectively. The levels achieved in the CSF, however, were equivalent to levels known to be cytocidal to malignant cell lines derived from tumors which metastasize to the central nervous system. Only one animal demonstrated neurotoxicity with IF. CSF levels of active metabolite in this animal were similar to those observed in the other animals.
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与环磷酰胺治疗大鼠血浆中 4-羟基环磷酰胺和磷酰胺芥子气浓度相关的细胞毒性活性。
影响因子：
11.2
作者：
Powers,JF;Sladek,NE
通讯作者：
Sladek,NE
DOI：
--
发表时间：
1981
期刊：
Cancer treatment reports
影响因子：
--
作者：
M. Colvin;J. Hilton
通讯作者：
M. Colvin;J. Hilton
异环磷酰胺治疗儿童恶性实体瘤的 II 期试验。
DOI：
--
发表时间：
1987
期刊：
Cancer treatment reports
影响因子：
--
作者：
Pratt,CB;Horowitz,ME;Meyer,WH;Etcubanas,E;Thompson,EI;Douglass,EC;Wilimas,JA;Hayes,FA;Green,AA
通讯作者：
Green,AA
在准备骨髓移植时反复给予高剂量环磷酰胺的患者中 4-羟基环磷酰胺和磷酰胺芥子气的血浆浓度。
DOI：
--
发表时间：
1984
期刊：
Cancer treatment reports
影响因子：
--
作者：
Sladek,NE;Doeden,D;Powers,JF;Krivit,W
通讯作者：
Krivit,W