Estimation of myocardial blood flow for longitudinal studies with N-13-labeled ammonia and positron emission tomography
Estimation of myocardial blood flow for longitudinal studies with N-13-labeled ammonia and positron emission tomography
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DOI：
10.1016/s1071-3581(96)90059-8
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发表时间：
1996-11-01
影响因子：
2.4
通讯作者：
Coleman, RE
中科院分区：
文献类型：
--
作者：
DeGrado, TR;Hanson, MW;Coleman, RE
背景，虽然已经开发并验证了几种建模策略，用于从N-13标记的氨正电子发射断层扫描数据定量心肌血流量（MBF），但缺乏对系列研究中各种技术的噪声特性的比较。在基线和药物应激后进行动态N-13标记的氨正电子发射断层扫描成像（1）对四只狗进行了单次研究，同时测量了微球血流量，以及（2）对八名正常志愿者进行了初始和随访研究。数据从对应于三个动脉血管区域的血池和心肌区域的短轴图像获得，MBF指数通过四种不同的技术获得：（1）加州大学，洛杉矶，二室模型，（2）密歇根二室模型，和（3）具有可变血容量项的一室模型，测量冠状动脉血流储备（CFR）作为应激/静息MBF的比率。测定了每种技术的静息和应激MBF和CFR研究之间相对变化的测量误差的估计标准差。所有技术的MBF估计值与犬心肌微球血流具有良好的相关性（r = 0.95至0.96）。在人体研究中，发现所有技术的MBF平均估计值相似，技术1和3显示MBE和CER的研究间变异性最小，这些技术的静息MBF、负荷MBF和CFR的估计标准差分别约为20%、30%和27%，结论。动态N-13标记的氨正电子发射断层扫描的MBF和CFR的无创定量用技术1或3最可重复，解释心肌部分容积差异的能力优先考虑技术3，然而，区域MBF的大量研究间变异性仍然存在，表明程序因素或MBF的真实的时间波动的重要性。
Background, Although several modeling strategies have been developed and validated for quantification of myocardial blood flow (MBF) from N-13-labeled ammonia positron emission tomographic data, a comparison of noise characteristics of the various techniques in serial studies is lacking.Methods and Results, Dynamic N-13-labeled ammonia positron emission tomographic imaging was performed at baseline and after pharmacologic stress in (1) single studies of four dogs with concomitant measurement of microsphere blood flow and (2) initial and follow-up studies of eight normal volunteers, Data were obtained from short-axis images for the blood pool and myocardial regions corresponding to the three arterial vascular territories, Indexes of MBF were obtained by four distinct techniques: (1) University of California, Los Angeles, two-compartment model, (2) Michigan two-compartment model, and (3) a one-compartment model with variable blood volume term, Coronary flow reserve (CFR) was measured as the ratio of stress/rest MBF. The estimated standard deviation of the measurement error for the relative change between studies of rest and stress MBF and CFR was determined for each technique, Estimates of MBF from all techniques showed good correlation with microsphere blood flow (r = 0.95 to 0.96) in canine myocardium. In human studies, similar mean estimates of MBF were found with all techniques, Techniques 1 and 3 showed the smallest interstudy variability in MBE and CER, The estimated standard deviations for these techniques were approximately 20%, 30%, and 27% for rest MBF, stress MBF, and CFR, respectively,Conclusion. Noninvasive quantification of MBF and CFR from dynamic N-13-labeled ammonia positron emission tomography is most reproducible with technique 1 or 3, The ability to account for differences in myocardial partial volume gives preference to technique 3, However, substantial interstudy variability in regional MBF remains, suggesting the importance of procedural factors or real temporal fluctuations in MBF.