Post-transcriptional regulatory network of epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions.
Post-transcriptional regulatory network of epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions.
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DOI：
10.1186/1756-8722-7-19
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发表时间：
2014-03-05
影响因子：
28.5
通讯作者：
Zhang W
中科院分区：
文献类型：
--
作者：
Guo F;Parker Kerrigan BC;Yang D;Hu L;Shmulevich I;Sood AK;Xue F;Zhang W
上皮-间充质转化（Epithelial-to-mesenchymal transition， EMT）及其逆向过程间充质-上皮转化（mesenchymal-to-epithelial transition， MET）在胚胎发生、干细胞生物学和癌症进展中发挥着重要作用。EMT可受多种信号通路和调控转录网络的调控。此外，转录后调控网络调控EMT；这些网络包括长链非编码RNA （lncRNA）和microRNA （miRNA）家族。具体来说，miR-200家族、miR-101、miR-506和几种lncrna已被发现调节EMT。最近的研究表明，几种lncrna在多种癌症中过表达，并通过诱导EMT促进肿瘤转移。MiRNA通过调节EMT转录因子或其他EMT调节因子来控制EMT，提示lncrna和MiRNA是治疗癌症的新靶点。进一步的研究表明，非编码介导的EMT调控通过启动子甲基化（如miR-200或miR-506）和蛋白质调控（如通过miR-502介导SET8）与表观遗传调控密切相关。基因融合的形成也被发现促进前列腺癌的EMT。在这篇综述中，我们讨论了EMT和MET的转录后调控网络，以及如何靶向EMT和MET为人类疾病提供有效的治疗方法。
Epithelial-to-mesenchymal transition (EMT) and its reverse process, mesenchymal-to-epithelial transition (MET), play important roles in embryogenesis, stem cell biology, and cancer progression. EMT can be regulated by many signaling pathways and regulatory transcriptional networks. Furthermore, post-transcriptional regulatory networks regulate EMT; these networks include the long non-coding RNA (lncRNA) and microRNA (miRNA) families. Specifically, the miR-200 family, miR-101, miR-506, and several lncRNAs have been found to regulate EMT. Recent studies have illustrated that several lncRNAs are overexpressed in various cancers and that they can promote tumor metastasis by inducing EMT. MiRNA controls EMT by regulating EMT transcription factors or other EMT regulators, suggesting that lncRNAs and miRNA are novel therapeutic targets for the treatment of cancer. Further efforts have shown that non-coding-mediated EMT regulation is closely associated with epigenetic regulation through promoter methylation (e.g., miR-200 or miR-506) and protein regulation (e.g., SET8 via miR-502). The formation of gene fusions has also been found to promote EMT in prostate cancer. In this review, we discuss the post-transcriptional regulatory network that is involved in EMT and MET and how targeting EMT and MET may provide effective therapeutics for human disease.
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作者：
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