Alcohol consumption and atherosclerosis: What is the relation? Prospective results from the Bruneck Study
Alcohol consumption and atherosclerosis: What is the relation? Prospective results from the Bruneck Study
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DOI：
10.1161/01.str.29.5.900
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发表时间：
1998-05-01
期刊：
影响因子：
8.3
通讯作者：
Bonora, E
中科院分区：
文献类型：
--
作者：
Kiechl, S;Willeit, J;Bonora, E
背景和目的-经常饮酒对动脉粥样硬化形成的潜在影响仍然是有争议的，主要是由于缺乏前瞻性的人口为基础的study.Methods-The Bruneck研究是一个前瞻性的人口为基础的动脉粥样硬化及其危险因素的调查。研究人群包括40至79岁的男性和女性的性别和年龄分层随机样本。参与和随访完成率超过90%。通过高分辨率双功超声检查监测1990年基线和1995年首次随访之间颈动脉粥样硬化的变化。酒精摄入量进行量化与标准化的问卷调查和前瞻性的饮食records.Results-Alcohol消费少于每周一次（偶尔饮酒）动脉粥样硬化没有影响。定期饮酒与颈动脉粥样硬化（早期动脉粥样硬化）之间的关系呈J形，轻度饮酒者面临的风险低于重度饮酒者或戒酒者。酒精消费提供的保护
Background and Purpose-Potential effects of regular alcohol consumption on atherogenesis are still controversial mainly due to the lack of prospective population-based studies.Methods-The Bruneck Study is a prospective population-based survey of atherosclerosis and its risk factors. The study population comprises a sex-and age-stratified random sample of men and women aged 40 to 79 years. Participation and follow-up were more than 90% complete. Changes in carotid atherosclerosis between the 1990 baseline and the first follow-up in 1995 were monitored by high-resolution duplex ultrasonography. Alcohol intake was quantified with a standardized questionnaire and prospective diet records.Results-Alcohol consumption less than once a week (occasional drinking) had no effect on atherogenesis. The association between regular alcohol intake and incident carotid atherosclerosis (early atherogenesis) was J-shaped, with light drinkers facing a lower risk than either heavy drinkers or abstainers. Protection offered by alcohol consumption of