South Asian men have different patterns of coronary artery disease when compared with European men
South Asian men have different patterns of coronary artery disease when compared with European men
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DOI：
10.1016/j.ijcard.2007.07.129
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发表时间：
2008-10-13
影响因子：
3.5
通讯作者：
Hughes, Alun
中科院分区：
文献类型：
--
作者：
Tillin, Therese;Dhutia, Harshil;Hughes, Alun
背景资料：比较英国南亚人和白色欧洲人的冠状动脉疾病模式。方法：研究了41名南亚人和42名欧洲人（平均年龄64 +/-9岁）的冠状动脉疾病。他们都有类似的症状。使用定量冠状动脉造影术计算血管参考直径和狭窄程度。采用多层螺旋CT测量的钙化评分（CAC）评估LAD中动脉粥样硬化疾病的程度。测量空腹血和血压。结果：大多数动脉粥样硬化发生在LAD近端，南亚男性LAD近端狭窄率高于欧洲男性（50%vs.37%，p = 0.036），但CAC评分相似。CAC评分处于最低三分位数（0 - 22 HU）的南亚人的LAD直径显著窄于欧洲人（2.8 mm vs. 3.8 mm，p = 0.004，经体表面积和年龄调整）。这种种族差异不能用测量的风险因素（包括糖尿病）来解释。相反，在CAC评分的上三分位数（23 - 2416 HU）中，LAD直径的种族差异消失（南亚人：3.0 mm，欧洲人：3.1 mm，p = 0.6）。钙化评分与欧洲人的LAD直径呈负相关（rho =-0.38，p =0.016），但在南亚人中不相关（rho =-0.06，p =0.72hclasses）：尽管钙化疾病水平相当，但南亚人的LAD狭窄增加归因于动脉狭窄。在欧洲人中，LAD直径减小与晚期疾病相关，但在南亚人中则无关，这表明血管重塑存在种族差异。(C)2007爱思唯尔爱尔兰有限公司保留所有权利。
Background: To compare patterns of coronary artery disease in British South Asian and White European men.Methods: 41 South Asian and 42 European men (mean age 64 +/- 9 years) with coronary artery disease were studied. All had similar symptoms. Vessel reference diameter and degree of stenosis were calculated using quantitative coronary angiography. Extent of atherosclerotic disease in the LAD was assessed using calcification scores (CAC) measured by multislice Computed Tomography. Fasting bloods and blood pressure were measured. The LAD was subdivided into four 2.5 cm segments for analysis.Results: Most atherosclerosis occurred in the proximal LAD segment, South Asian men had more proximal LAD stenosis than European men (50% vs. 37%, p=0.036), but CAC scores were similar. South Asians with CAC scores in the lowest tertile (0-22 HU), had significantly narrower LAD diameters than Europeans (2.8 mm vs. 3.8 mm, p=0.004, adjusted for body surface area and age). This ethnic difference was not explained by measured risk factors, including diabetes. In contrast, ethnic differences in LAD diameter were abolished in the upper tertiles of CAC scores (23-2416 HU) (South Asians: 3.0 mm, Europeans: 3.1 mm, p=0.6). Calcification scores were negatively correlated with LAD diameter in Europeans (rho=-0.38, p=0.016) but not in South Asians (rho=-0.06, p=0.72).Conclusions: Increased LAD stenosis, despite equivalent levels of calcified disease, in South Asians is attributable to narrower arteries. Reduced LAD diameter is associated with advanced disease in Europeans but not in South Asians, indicative of ethnic differences in vascular remodelling. (C) 2007 Elsevier Ireland Ltd. All rights reserved.