Comparison of Polymyxin B, Tigecycline, Cefepime, and Meropenem MICs for KPC-Producing Klebsiella pneumoniae by Broth Microdilution, Vitek 2, and Etest
Comparison of Polymyxin B, Tigecycline, Cefepime, and Meropenem MICs for KPC-Producing Klebsiella pneumoniae by Broth Microdilution, Vitek 2, and Etest
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DOI：
10.1128/jcm.02534-10
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发表时间：
2011-05-01
影响因子：
9.4
通讯作者：
Kubin, Christine J.
中科院分区：
文献类型：
--
作者：
Lat, Asma;Clock, Sarah A.;Kubin, Christine J.
我们报告了肉汤微量稀释法（BMD）、Vitek 2和Etest对48株临床产KPC肺炎克雷伯菌分离株的多粘菌素B、替加环素、头孢吡肟和美罗培南的MIC一致性和错误率。两种商业检测方法均适用于替加环素检测; Etest提供了多粘菌素B敏感性的保守估计。我们建议实验室考虑补充使用头孢吡肟和美罗培南的参考BMD或Etest进行产KPC的K的药敏试验。肺炎，因为Vitek 2没有提供可靠的结果。
We report MIC agreement and error rates between broth microdilution (BMD), Vitek 2, and Etest against 48 clinical KPC-producing Klebsiella pneumoniae isolates for polymyxin B, tigecycline, cefepime, and meropenem. Both commercial testing methods were useful for tigecycline testing; Etest provided a conservative estimate of polymyxin B susceptibility. We suggest that laboratories consider the supplemental use of reference BMD or Etest for cefepime and meropenem for susceptibility testing of KPC-producing K. pneumoniae, as Vitek 2 did not provide reliable results.