Gold(III) porphyrins as a new class of anticancer drugs: cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells
Gold(III) porphyrins as a new class of anticancer drugs: cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells
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DOI：
10.1039/b303294a
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发表时间：
2003-01-01
影响因子：
4.9
通讯作者：
Sun, HZ
中科院分区：
文献类型：
--
作者：
Che, CM;Sun, RWY;Sun, HZ
一系列金（III）四芳基卟啉在谷胱甘肽存在下是稳定的，并且在杀死人类癌细胞（包括耐药变异）方面发挥比顺铂高得多的效力；根据激光共聚焦显微镜和流式细胞术研究，金诱导的细胞毒性是通过凋亡途径发生的。
A series of gold(III) tetraarylporphyrins are stable in the presence of glutathione and exert much higher potency than cisplatin in killing human cancer cells, including the drug-resistant variants; the gold-induced cytotoxicity occurs through an apoptotic pathway according to laser confocal microscopy and flow cytometric studies.