Nosocomial infections in the intensive care unit: Incidence, risk factors, outcome and associated pathogens in a public tertiary teaching hospital of Eastern India.
Nosocomial infections in the intensive care unit: Incidence, risk factors, outcome and associated pathogens in a public tertiary teaching hospital of Eastern India.
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DOI：
10.4103/0972-5229.148633
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发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Hazra A
中科院分区：
文献类型：
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作者：
Dasgupta S;Das S;Chawan NS;Hazra A
重症监护病房（ICU）中与医院感染相关的发病率和死亡率的增加是当今严重关注的问题。确定三级护理教学医院ICU获得性医院感染的发生率、危险因素、致病病原体和结局。这是一项前瞻性观察性研究，在一所医学院医院的12床内外科联合ICU中进行。研究组包括242名在ICU住院超过48小时的患者。收集有关疾病严重程度、ICU入院的主要原因、存在的危险因素、存在的感染、感染因子、ICU时间和住院时间以及生存状态的数据，并进行Logistic回归分析。医院感染率为11.98%（95%可信区间7.89-16.07%）。肺炎是最常见的感染（62.07%），其次是尿路感染和中心静脉导管相关性血流感染。既往抗菌药物治疗、导尿术和ICU住院时间是与医院感染相关的统计学显著危险因素。医院感染导致ICU时间和住院时间的统计学显著增加，但死亡率没有增加。医院感染增加了住院患者的发病率。这些发现可用于规划我们环境中的医院感染监测计划。
The increased morbidity and mortality associated with nosocomial infections in the intensive care unit (ICU) is a matter of serious concern today. To determine the incidence of nosocomial infections acquired in the ICU, their risk factors, the causative pathogens and the outcome in a tertiary care teaching hospital. This was a prospective observational study conducted in a 12 bedded combined medical and surgical ICU of a medical college hospital. The study group comprised 242 patients admitted for more than 48 h in the ICU. Data were collected regarding severity of the illness, primary reason for ICU admission, presence of risk factors, presence of infection, infecting agent, length of ICU and hospital stay, and survival status and logistic regression analysis was done. The nosocomial infection rate was 11.98% (95% confidence interval 7.89–16.07%). Pneumonia was the most frequently detected infection (62.07%), followed by urinary tract infections and central venous catheter associated bloodstream infections. Prior antimicrobial therapy, urinary catheterization and length of ICU stay were found to be statistically significant risk factors associated with nosocomial infection. Nosocomial infection resulted in a statistically significant increase in length of ICU and hospital stay, but not in mortality. Nosocomial infections increase morbidity of hospitalized patients. These findings can be utilized for planning nosocomial infection surveillance program in our setting.