Auditory ERPs to Stimulus Deviance in an Awake Chimpanzee (Pan troglodytes): Towards Hominid Cognitive Neurosciences
Auditory ERPs to Stimulus Deviance in an Awake Chimpanzee (Pan troglodytes): Towards Hominid Cognitive Neurosciences
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DOI：
10.1371/journal.pone.0001442
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发表时间：
2008-01-16
期刊：
影响因子：
3.7
通讯作者：
Hasegawa, Toshikazu
中科院分区：
文献类型：
--
作者：
Ueno, Ari;Hirata, Satoshi;Hasegawa, Toshikazu
背景几十年来，黑猩猩，在遗传学上最接近人类，在比较认知研究中被深入分析。除了行为数据的积累，黑猩猩认知过程的神经基础还有待澄清。为了增加我们对人类认知的进化和神经基础的认识，需要对清醒状态下内源性神经活动进行比较神经生理学研究。然而，到目前为止，这种研究很少在非人类的原始人类物种中报道，因为在清醒的个体上进行非侵入性测量存在实际困难。方法/主要调查结果。我们测量了一只完全清醒的黑猩猩的听觉事件相关电位（ERP），并参考了人类研究的一个有据可查的组成部分，即失配负波（MMN）。响应于在均匀的声音流中传递的不频繁的异常音调，可以检测到类似的ERP分量作为在早期lavage中的负偏转。结论/意义。本研究首次报道了黑猩猩中的MMN样成分。在人类研究中，各种ERP组件，包括MMN，是认知和神经处理的良好记录指标。本研究的结果验证了使用非侵入性ERP测量的研究在黑猩猩的认知和神经加工，并开辟了道路，为未来的研究比较内源性神经活动之间的人类和黑猩猩。这标志着人类认知神经科学的重要一步。
Background. For decades, the chimpanzee, phylogenetically closest to humans, has been analyzed intensively in comparative cognitive studies. Other than the accumulation of behavioral data, the neural basis for cognitive processing in the chimpanzee remains to be clarified. To increase our knowledge on the evolutionary and neural basis of human cognition, comparative neurophysiological studies exploring endogenous neural activities in the awake state are needed. However, to date, such studies have rarely been reported in non-human hominid species, due to the practical difficulties in conducting non-invasive measurements on awake individuals. Methodology/Principal Findings. We measured auditory event-related potentials (ERPs) of a fully awake chimpanzee, with reference to a well-documented component of human studies, namely mismatch negativity (MMN). In response to infrequent, deviant tones that were delivered in a uniform sound stream, a comparable ERP component could be detected as negative deflections in early latencies. Conclusions/Significance. The present study reports the MMN-like component in a chimpanzee for the first time. In human studies, various ERP components, including MMN, are well-documented indicators of cognitive and neural processing. The results of the present study validate the use of noninvasive ERP measurements for studies on cognitive and neural processing in chimpanzees, and open the way for future studies comparing endogenous neural activities between humans and chimpanzees. This signifies an essential step in hominid cognitive neurosciences.