Rapid, efficient synthesis of heterobifunctional biodegradable dendrimers
Rapid, efficient synthesis of heterobifunctional biodegradable dendrimers
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DOI：
10.1021/ja071530z
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发表时间：
2007-06-06
影响因子：
15
通讯作者：
Frechet, Jean M. J.
中科院分区：
文献类型：
--
作者：
Goodwin, Andrew P.;Lam, Stephanie S.;Frechet, Jean M. J.
本文描述了一种制备杂双功能可生物降解树状大分子的方法，该方法涉及制备由2,2-二（羟甲基）丙酸衍生的对称脂肪酯树状大分子，该树状大分子具有环状碳酸盐外围，随后用功能胺打开碳酸盐部分。这种方法不需要色谱纯化步骤，证明了树状分子的制备具有8个受保护的醛和8个炔在其外围。
A method for the preparation of heterobifunctional biodegradable dendrimers is described involving the preparation of a symmetric aliphatic ester dendrimer derived from 2,2-bis(hydroxymethyl)propanoic acid bearing a cyclic carbonate periphery, followed by opening of the carbonate moieties with a functional amine. This approach requiring no chromatographic purification steps was demonstrated with the preparation of a dendrimer bearing eight protected aldehydes and eight alkynes at its periphery.