Amyloid beta-protein toxicity and oxidative stress in Alzheimer's disease.
Amyloid beta-protein toxicity and oxidative stress in Alzheimer's disease.
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作者：
C. Behl
阿尔茨海默病(AD)是一种以记忆丧失和认知能力进行性下降为特征的神经退行性疾病。虽然这种疾病的发病机制尚不清楚，而且仍在深入研究中，但有几种假说解决了这种疾病的某些方面。本文综述了AD的氧化应激假说，以及为预防和治疗这种神经退行性疾病提供有效神经保护的新的抗氧化方法。讨论了AD相关淀粉样β蛋白(Abeta)的毒性，Abeta对神经元的氧化应激诱导，以及脑组织氧化事件的潜在来源。
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by loss of memory and progressive decline of cognitive abilities. Although the pathogenesis of this disease is not known and is still under intensive investigation, there are several hypotheses which address certain aspects of the disease. This review focuses on the oxidative-stress hypothesis of AD and on novel antioxidative approaches to an effective neuroprotection for the prevention and therapy of this neurodegenerative disorder. The toxicity of the AD-associated amyloid beta-protein (Abeta), the induction of oxidative stress by Abeta in neurons, and potential sources of oxidative events in brain tissue are discussed.