The Role of B Cells in Adult and Paediatric Liver Injury.
The Role of B Cells in Adult and Paediatric Liver Injury.
复制标题
B细胞在成人和小儿肝损伤中的作用。
DOI：
10.3389/fimmu.2021.729143
复制
发表时间：
2021
影响因子：
7.3
通讯作者：
Stamataki Z
中科院分区：
文献类型：
--
作者：
Patel AM;Liu YS;Davies SP;Brown RM;Kelly DA;Scheel-Toellner D;Reynolds GM;Stamataki Z
B淋巴细胞是多任务细胞，通过产生促炎性或抗炎性细胞因子，通过为T细胞激活和共同刺激呈递经过处理的抗原，以及转化为抗体分泌细胞来指导免疫反应。这些功能对控制肝脏感染很重要，但也可能加剧组织损伤和纤维化，作为持续炎症的一部分，可能导致需要移植的终末期疾病。在移植中，免疫抑制增加了淋巴瘤的发生率，而这通常是源于B细胞。在这篇综述中，我们汇集了来自不同肝脏疾病的肝脏B细胞生物学信息，包括酒精相关和代谢性脂肪性肝病、自身免疫性肝炎、原发性胆道和原发性硬化性胆管炎、病毒性肝炎和婴儿胆道闭锁。我们还讨论了B细胞消耗疗法在肝脏环境中的影响。综上所述，我们的分析表明，B细胞在肝脏疾病的发病机制中很重要，需要进一步的研究来充分表征人类肝脏B细胞区室。
B lymphocytes are multitasking cells that direct the immune response by producing pro- or anti-inflammatory cytokines, by presenting processed antigen for T cell activation and co-stimulation, and by turning into antibody-secreting cells. These functions are important to control infection in the liver but can also exacerbate tissue damage and fibrosis as part of persistent inflammation that can lead to end stage disease requiring a transplant. In transplantation, immunosuppression increases the incidence of lymphoma and often this is of B cell origin. In this review we bring together information on liver B cell biology from different liver diseases, including alcohol-related and metabolic fatty liver disease, autoimmune hepatitis, primary biliary and primary sclerosing cholangitis, viral hepatitis and, in infants, biliary atresia. We also discuss the impact of B cell depletion therapy in the liver setting. Taken together, our analysis shows that B cells are important in the pathogenesis of liver diseases and that further research is necessary to fully characterise the human liver B cell compartment.