Drinking-induced bradyarrhythmias and cerebral injury in Dahl salt-sensitive rats with sinoaortic denervation.
Drinking-induced bradyarrhythmias and cerebral injury in Dahl salt-sensitive rats with sinoaortic denervation.
复制标题
窦主动脉去神经术对 Dahl 盐敏感大鼠的饮酒引起的缓慢性心律失常和脑损伤。
DOI：
10.1152/japplphysiol.00866.2013
复制
发表时间：
2013
期刊：
影响因子：
3.3
通讯作者：
Morita H.
中科院分区：
文献类型：
--
作者：
Abe C;Morita H.
我们已经证明，饮酒引起的升压反应是较大的，如果压力反射不工作，平均动脉压达到163毫米汞柱清醒大鼠与窦主动脉去神经（SAD）。因此，我们假设，如果基础动脉压高，饮酒行为成为心血管疾病的危险因素。为了澄清这一点，我们分析了心律失常的发生和小胶质细胞的积累在达尔盐敏感大鼠（达尔S）SAD。我们用高钠饮食维持Dahl S和Dahl耐盐大鼠（Dahl R）5周。SAD手术后，我们测量了所有大鼠饮水行为期间的动脉压和心电图。此外，我们还测定了大鼠脑脊液（CSF）中肿瘤坏死因子-α（TNF-α）浓度和第三和第四脑室周围小胶质细胞的积聚，这些大鼠以快速或慢速程序性饮水持续7天。Dahl S大鼠饮酒诱导的缓慢性心律失常和室性早搏（PVC）的发生率显著高于Dahl R大鼠。阿托品给药可完全消除缓慢性心律失常和PVC。在快速饮水的大鼠中观察到第三脑室周围小胶质细胞积聚和CSF中TNF-α升高;在缓慢饮水的大鼠中未观察到这些情况。总之，在SAD的Dahl S大鼠中，饮酒可能增加心血管事件和脑损伤。这些风险可以通过改变饮酒行为来降低，例如减慢饮酒速度。
We have demonstrated that a drinking-induced pressor response was larger if the baroreflex did not operate, and the mean arterial pressure reached 163 mmHg in conscious rats with sinoaortic denervation (SAD). Thus we hypothesized that a drinking behavior became a cardiovascular risk factor if a basal arterial pressure was high. To clarify this, we analyzed the occurrence of arrhythmias and the accumulation of microglia in Dahl salt-sensitive rats (Dahl S) with SAD. We maintained Dahl S and Dahl salt-resistant rats (Dahl R) with a high-sodium diet for 5 weeks. After SAD surgery, we measured arterial pressure and electrocardiogram during water-drinking behavior in all rats. Furthermore, we measured tumor necrosis factor-α concentration in the cerebrospinal fluid (CSF) and microglial accumulations around the third and fourth ventricles in rats with programmed drinking at a rapid or slow rate for 7 days. Incidences of drinking-induced bradyarrhythmias and premature ventricular contractions (PVCs) were significantly larger in Dahl S than Dahl R rats. Both bradyarrhythmias and PVCs were completely abolished by atropine administration. Accumulations of microglia around the third ventricle and increases in TNF-α in the CSF were observed in rats that drank water at a rapid rate; these were not seen in rats that drank water slowly. In conclusion, both cardiovascular events and cerebral injury may be increased by drinking in Dahl S rats with SAD. These risks are reduced by modifying drinking behavior such as slowing the drinking rate.