INTERLEUKIN-6 INDUCED AT MUCOSAL SURFACES BY GRAM-NEGATIVE BACTERIAL-INFECTION
INTERLEUKIN-6 INDUCED AT MUCOSAL SURFACES BY GRAM-NEGATIVE BACTERIAL-INFECTION
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DOI：
10.1128/iai.57.11.3383-3388.1989
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发表时间：
1989-11-01
影响因子：
3.1
通讯作者：
EDEN, CS
中科院分区：
文献类型：
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作者：
DEMAN, P;VANKOOTEN, C;EDEN, CS
白介素 6 (IL-6) 是针对革兰氏阴性菌小鼠的粘膜和全身感染而产生的。 IL-6 反应由脂多糖基因 Lps 控制；在 C3H/HeN 小鼠 (Lpsn/Lpsn) 中，大肠杆菌攻击后 30 分钟内尿 IL-6 水平增加，但在 C3H/HeJ 小鼠 (Lpsd/Lpsd) 中没有出现反应。在脂多糖应答小鼠中，局部和全身IL-6的水平与感染程度相关。膀胱内激发后以尿反应为主，腹膜内激发后以血清反应为主。结果表明，IL-6 作为脂多糖诱导的粘膜和全身对革兰氏阴性细菌感染反应的一部分而被激活。
Interleukin-6 (IL-6) was produced in response to mucosal and systemic infection of mice with gram-negative bacteria. The IL-6 response was controlled by the lipopolysaccharide gene, Lps; in C3H/HeN mice (Lpsn/Lpsn), the urinary IL-6 levels increased within 30 min after challenge with Escherichia coli, but no response occurred in C3H/HeJ mice (Lpsd/Lpsd). In lipopolysaccharide-responder mice, the levels of local and systemic IL-6 were related to the degree of infection. The urinary response dominated after intravesical challenge, and the serum response dominated after intraperitoneal challenge. The results demonstrate that IL-6 is activated as part of lipopolysaccharide-induced mucosal and systemic responses to gram-negative bacterial infections.