The independence of intrinsic radiosensitivity as a prognostic factor for patient response to radiotherapy of carcinoma of the cervix.
The independence of intrinsic radiosensitivity as a prognostic factor for patient response to radiotherapy of carcinoma of the cervix.
复制标题
内在放射敏性作为对子宫颈癌放射疗法的患者反应的预后因素的独立性。
DOI：
10.1038/bjc.1997.531
复制
发表时间：
1997
影响因子：
8.8
通讯作者：
Hunter, R D
中科院分区：
文献类型：
--
作者：
West, C M;Davidson, S E;Roberts, S A;Hunter, R D
对128例接受放射治疗的I-III期宫颈癌患者进行了肿瘤放射敏感性（2戈伊时的存活分数，SF 2）预处理测量的预后价值研究。中位随访时间为47个月。在根据中位数对患者进行分层的单变量分析中，放射敏感性是总生存率、局部控制和无转移生存率的重要预后因素。SF 2值低于中位数的肿瘤的5年生存率为81%，显著高于SF 2值高于中位数的肿瘤的5年生存率51%。在双变量分析中，SF 2被证明是独立的疾病阶段，肿瘤分级，患者年龄，集落形成效率和肿瘤直径。在多变量分析中，放射敏感性是最重要的变量，考虑到这一点，只有分期是治疗结果的重要独立预测因素。这些数据表明，在宫颈癌放疗治疗，治疗前肿瘤固有的放射敏感性是一个重要的预后参数，并有助于独立于其他既定的和推定的参数的预后。
A study was made of the prognostic value of pretreatment measurements of tumour radiosensitivity (surviving fraction at 2 Gy, SF2) in 128 patients with stage I-III carcinomas of the uterine cervix undergoing radiotherapy. The median follow-up time was 47 months. In a univariate analysis stratifying patients according to the median value, radiosensitivity was a significant prognostic factor for overall survival, local control and metastasis-free survival. The 5-year survival rate for tumours with SF2 values below the median was 81% and was significantly greater than the rate of 51% for those with SF2 values above the median. In bivariate analyses, SF2 was shown to be independent of disease stage, tumour grade, patient age, colony-forming efficiency and tumour diameter. In a multivariate analysis, radiosensitivity was the most important variable and, after allowing for this, only stage was a significant independent predictor of treatment outcome. These data indicate that, in carcinoma of the cervix treated with radiotherapy, pretreatment tumour intrinsic radiosensitivity is an important prognostic parameter and contributes to prognosis independently of other established and putative parameters.