MECHANISMS IN RETINAL VASCULOGENESIS - AN ANALYSIS OF THE SPATIAL BRANCHING SITE CORRELATION
MECHANISMS IN RETINAL VASCULOGENESIS - AN ANALYSIS OF THE SPATIAL BRANCHING SITE CORRELATION
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DOI：
10.3109/02713689509033522
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发表时间：
1995-04-01
影响因子：
2
通讯作者：
DAXER, A
中科院分区：
文献类型：
--
作者：
DAXER, A
从视网膜血管模式的分形维数计算开始，提出了不同的生长模型和相关机制来模拟视网膜血管发生。不存在对该主题的全面看法。为了阐明这个问题，对胚胎血管模式的血管分支位点的空间相关性进行了研究。在神经纤维层内视网膜脉管系统的发育过程中，可以观察到分支特征的改变。这一结果支持了以下理论：血管传播与侵入血管细胞和视网膜组织的结构和表面特征之间存在密切关系。然而，动静脉分化可能由扩散过程主导。
Starting from fractal dimension calculations of retinal vessel patterns, different growth models and related mechanisms have been suggested to simulate retinal vasculogenesis. A comprehensive view of this topic does not exist. In order to elucidate this question the spatial correlation of the vessel branching sites of the embryonic vessel pattern has been studied. During development of the retinal vasculature within the nerve fiber layer a modification of the branching characteristics can be observed. This result supports theories which suggest a close relation between the vessel propagation and the structure and surface characteristics of the invading vascular cells and the retinal tissue. Arterio-venous differentiation, however, may be dominated by diffusion processes.