Immunosenescence and organ transplantation
Immunosenescence and organ transplantation
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DOI：
10.1016/j.trre.2013.03.001
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发表时间：
2013-07-01
影响因子：
4
通讯作者：
Tullius, Stefan G.
中科院分区：
文献类型：
--
作者：
Heinbokel, Timm;Elkhal, Abdallah;Tullius, Stefan G.
越来越多的老年移植受者和对老年捐赠者器官的需求不断增长，给移植医学带来了紧迫的挑战。与衰老平行的免疫系统的连续和复杂的修饰对移植结果和器官质量有重大影响。同种免疫反应的改变和器官免疫原性的增加都是降低患者和移植物存活率的危险因素。此外，越来越多的知识对年龄依赖性的修改同种异体识别和同种异体免疫反应可能需要年龄适应性免疫抑制和器官allocation.Here，我们总结了免疫衰老的相关方面和它们可能对器官移植的临床影响。(C)2013 Elsevier Inc. All rights reserved.
Increasing numbers of elderly transplant recipients and a growing demand for organs from older donors impose pressing challenges on transplantation medicine. Continuous and complex modifications of the immune system in parallel to aging have a major impact on transplant outcome and organ quality. Both, altered alloimmune responses and increased immunogenicity of organs present risk factors for inferior patient and graft survival. Moreover, a growing body of knowledge on age-dependent modifications of allorecognition and alloimmune responses may require age-adapted immunosuppression and organ allocation.Here, we summarize relevant aspects of immunosenescence and their possible clinical impact on organ transplantation. (C) 2013 Elsevier Inc. All rights reserved.