Traditional and Digital Biomarkers: Two Worlds Apart?
Traditional and Digital Biomarkers: Two Worlds Apart?
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DOI：
10.1159/000502000
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发表时间：
2019-05-01
影响因子：
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通讯作者：
Miho, Enkelejda
中科院分区：
文献类型：
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作者：
Babrak, Lmar M;Menetski, Joseph;Miho, Enkelejda
生物标志物在临床和医学领域的识别和应用对社会产生了巨大的影响。数字设备的增加和与健康相关的移动的应用程序的普及，在大量、多样和复杂的数据中产生了新的生物标志物宝库。然而，数字生物标志物的定义不明确，人群群体，以及它们与传统生物标志物的交叉阻碍了它们的发现和验证。我们已经确定了数字生物标志物领域的当前问题，并在DayOne研讨会期间与来自学术界和工业界的参与者提出了解决这些问题的建议。我们发现了传统生物标志物和数字生物标志物之间的相似性和差异，以便同步语义，定义独特的特征，审查当前的监管程序，并描述能够实现精准医学的新应用。
The identification and application of biomarkers in the clinical and medical fields has an enormous impact on society. The increase of digital devices and the rise in popularity of health-related mobile apps has produced a new trove of biomarkers in large, diverse, and complex data. However, the unclear definition of digital biomarkers, population groups, and their intersection with traditional biomarkers hinders their discovery and validation. We have identified current issues in the field of digital biomarkers and put forth suggestions to address them during the DayOne Workshop with participants from academia and industry. We have found similarities and differences between traditional and digital biomarkers in order to synchronize semantics, define unique features, review current regulatory procedures, and describe novel applications that enable precision medicine.