FUNCTIONAL MRI OF SWALLOWING: FROM NEUROPHYSIOLOGY TO NEUROPLASTICITY
FUNCTIONAL MRI OF SWALLOWING: FROM NEUROPHYSIOLOGY TO NEUROPLASTICITY
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DOI：
10.1002/hed.21903
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发表时间：
2011-10-01
影响因子：
2.9
通讯作者：
Robbins, JoAnne
中科院分区：
文献类型：
--
作者：
Malandraki, Georgia A.;Johnson, Sterling;Robbins, JoAnne
吞咽是一个复杂的神经源性感觉运动过程，涉及各级神经轴以及大量的肌肉和解剖结构。这些解剖或功能成分的任何破坏都可能导致吞咽障碍（也称为吞咽困难）。了解控制吞咽的神经通路对于诊断和治疗吞咽困难患者是必要的。功能性磁共振成像 (fMRI) 是一种流行且有效的神经成像方法，已用于研究体内吞咽的复杂神经生理控制。本文总结了使用功能磁共振成像研究正常受试者和吞咽困难患者吞咽神经控制的研究，并探讨吞咽治疗对神经可塑性的影响。讨论了方法学挑战和注意事项，并提出了治疗前范例的案例研究，以强调功能磁共振成像在吞咽研究和临床实践中应用的潜在未来方向。 (C) 2011 年 Wiley 期刊公司。头颈 33：S14-S20，2011 年
Swallowing is a complex neurogenic sensorimotor process involving all levels of the neuraxis and a vast number of muscles and anatomic structures. Disruption of any of these anatomic or functional components can lead to swallowing disorders (also known as dysphagia). Understanding the neural pathways that govern swallowing is necessary in diagnosing and treating patients with dysphagia. Functional MRI (fMRI) is a prevalent and effective neuroimaging method that has been used to study the complex neurophysiologic control of swallowing in vivo. This article presents a summary of the research studies that have used fMRI to study the neural control of swallowing in normal subjects and dysphagic patients, and to investigate the effects of swallowing treatments on neuroplasticity. Methodologic challenges and caveats are discussed, and a case study of a pre-posttreatment paradigm is presented to highlight potential future directions of fMRI applications in swallowing research and clinical practice. (C) 2011 Wiley Periodicals, Inc. Head Neck 33: S14-S20, 2011