MiR-122 Induces Radiosensitization in Non-Small Cell Lung Cancer Cell Line.
MiR-122 Induces Radiosensitization in Non-Small Cell Lung Cancer Cell Line.
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DOI：
10.3390/ijms160922137
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发表时间：
2015-09-14
影响因子：
5.6
通讯作者：
Feng F
中科院分区：
文献类型：
--
作者：
Ma D;Jia H;Qin M;Dai W;Wang T;Liang E;Dong G;Wang Z;Zhang Z;Feng F
MIR-122是一种新的肿瘤抑制因子，其表达可诱导细胞周期停滞或凋亡，并抑制包括非小细胞肺癌(NSCLC)在内的多种癌细胞的增殖。肿瘤细胞的放射抵抗是非小细胞肺癌放射治疗的主要缺陷，诱导放射增敏可能是解决这一问题的有效策略。本工作研究了miR-122在非小细胞肺癌细胞A549诱导放射增敏中的作用。MIR-122对A549细胞具有放射增敏作用。MIR-122还增强了电离辐射(IR)对癌细胞锚非依赖性生长和侵袭的抑制活性。此外，miR-122减少了与肿瘤存活或细胞应激反应相关的靶基因的表达。这些结果表明miR-122有望成为非小细胞肺癌放射治疗的一种新策略。
MiR-122 is a novel tumor suppresser and its expression induces cell cycle arrest, or apoptosis, and inhibits cell proliferation in multiple cancer cells, including non-small cell lung cancer (NSCLC) cells. Radioresistance of cancer cell leads to the major drawback of radiotherapy for NSCLC and the induction of radiosensitization could be a useful strategy to fix this problem. The present work investigates the function of miR-122 in inducing radiosensitization in A549 cell, a type of NSCLC cells. MiR-122 induces the radiosensitization of A549 cells. MiR-122 also boosts the inhibitory activity of ionizing radiation (IR) on cancer cell anchor-independent growth and invasion. Moreover, miR-122 reduced the expression of its targeted genes related to tumor-survival or cellular stress response. These results indicate that miR-122 would be a novel strategy for NSCLC radiation-therapy.